N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine

Base Information

Chemical Name:N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine
CAS No.:1097917-15-1
Molecular Formula:C29H40N8O3S
Molecular Weight:580.754
Hs Code.:
Mol file:1097917-15-1.mol

Synonyms:N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine;

Suppliers and Price of N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
ASP 3026
10mg
$ 446.00

TRC
ASP3026
10mg
$ 140.00

Tocris
ASP3026 ≥99%(HPLC)
10
$ 185.00

Tocris
ASP3026 ≥99%(HPLC)
50
$ 778.00

Matrix Scientific
N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine 95%
5g
$ 12210.00

Matrix Scientific
N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine 95%
1g
$ 4070.00

DC Chemicals
ASP3026 >98%
1 g
$ 1600.00

DC Chemicals
ASP3026 >98%
100 mg
$ 400.00

Crysdot
ASP3026 98+%
10mg
$ 76.00

Crysdot
ASP3026 98+%
5mg
$ 59.00

Total 34 raw suppliers

Chemical Property of N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine

Chemical Property:

Boiling Point:794.3±70.0 °C(Predicted)
PKA:8.14±0.42(Predicted)
PSA：127.43000
Density:1.276
LogP:4.28220
Solubility.:insoluble in H2O; ≥14.53 mg/mL in DMSO; ≥4.9 mg/mL in EtOH with gentle warming and ultrasonic

Purity/Quality:

99%, ^*data from raw suppliers

ASP 3026 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description ASP3026 is an ATP-competitive, second-generation ALK inhibitor (IC50 = 3.5 nM) that also inhibits ROS (IC50 = 8.9 nM) and ACK (IC50 = 5.8 nM). It inhibits neuroblastoma-activating ALK mutants F1174L (IC50 = 10 nM) and R1275Q (IC50 = 5.4 nM) and demonstrates antitumor activity in xenograft mouse models. ASP3026 has been shown to overcome crizotinib resistance in non-small cell lung cancer, and is currently being evaluated in clinical trials of patients with ALK-positive solid tumors.
Uses ASP3026 is a novel and selective anaplastic lymphoma kinase (ALK) inhibitor that shows potent anti-tumor activities. ASP3026 also shows potential efficacy for non-small cell lung cancer (NSCLC) and is expected to improve the therapeutic outcomes of patients with cancer with ALK abnormality. Potent ALK inhibitor.

Technology Process of N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine

There total 20 articles about N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 109-01-3
1-methyl-piperazine

: 1097917-68-4
1-[3-methoxy-4-({4-[2-(propane-2-sulfonyl)anilino]-1,3,5-triazin-2-yl}amino)phenyl]piperidin-4-one

: 1097917-15-1
N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)-piperidin-1-yl]phenyl}-N′-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 40 ℃; for 7h; under 1861.76 Torr; Concentration; Reagent/catalyst; Solvent; Temperature; Time;

Reference yield: 57.0%

: 2-methoxy-4-[4-(4-methylpiperazin-1-yl)-piperidin-1-yl]-phenylamine

: 1097920-74-5
4-chloro-N-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazin-2-amine

: 1097917-15-1
N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)-piperidin-1-yl]phenyl}-N′-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine

Guidance literature:: 2-methoxy-4-[4-(4-methylpiperazin-1-yl)-piperidin-1-yl]-phenylamine; With methanesulfonic acid; In ethanol; at 20 ℃; for 0.25h;

4-chloro-N-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazin-2-amine; In ethanol; at 100 ℃; for 2h;
DOI:10.1248/cpb.c17-00784

Reference yield: 50.1%

: 2-methoxy-4-[4-(4-methylpiperazin-1-yl)-piperidin-1-yl]-phenylamine

: 761440-65-7
1-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine

: 1097917-15-1
N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)-piperidin-1-yl]phenyl}-N′-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine

Guidance literature:: 2-methoxy-4-[4-(4-methylpiperazin-1-yl)-piperidin-1-yl]-phenylamine; With methanesulfonic acid; In ethanol; at 20 ℃; for 0.25h;

1-[1-(3-methoxy-4-nitrophenyl)piperidin-4-yl]-4-methylpiperazine; In ethanol; at 100 ℃; for 5h;