1-[3-methoxy-4-({4-[2-(propane-2-sulfonyl)anilino]-1,3,5-triazin-2-yl}amino)phenyl]piperidin-4-one

Base Information

• Chemical Name: 1-[3-methoxy-4-({4-[2-(propane-2-sulfonyl)anilino]-1,3,5-triazin-2-yl}amino)phenyl]piperidin-4-one
• CAS No.: 1097917-68-4
• Molecular Formula: C₂₄H₂₈N₆O₄S
• Molecular Weight: 496.59
• Mol file: 1097917-68-4.mol

Synonyms:1-[3-methoxy-4-({4-[2-(propane-2-sulfonyl)anilino]-1,3,5-triazin-2-yl}amino)phenyl]piperidin-4-one

Chemical Property of 1-[3-methoxy-4-({4-[2-(propane-2-sulfonyl)anilino]-1,3,5-triazin-2-yl}amino)phenyl]piperidin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[3-methoxy-4-({4-[2-(propane-2-sulfonyl)anilino]-1,3,5-triazin-2-yl}amino)phenyl]piperidin-4-one

There total 14 articles about 1-[3-methoxy-4-({4-[2-(propane-2-sulfonyl)anilino]-1,3,5-triazin-2-yl}amino)phenyl]piperidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%

N-[4-(4,4-dimethoxypiperidin-1-yl)-2-methoxyphenyl]-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine → 1-[3-methoxy-4-({4-[2-(propane-2-sulfonyl)anilino]-1,3,5-triazin-2-yl}amino)phenyl]piperidin-4-one (1097917-68-4)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; isopropyl alcohol; at 20 ℃; for 17.5h; Concentration; Time;

Reference yield: 92.0%

6-chloro-N2-[4-(4,4-dimethoxypiperidin-1-yl)-2-methoxyphenyl]-N4-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine → 1-[3-methoxy-4-({4-[2-(propane-2-sulfonyl)anilino]-1,3,5-triazin-2-yl}amino)phenyl]piperidin-4-one (1097917-68-4)

Guidance literature:

6-chloro-N₂-[4-(4,4-dimethoxypiperidin-1-yl)-2-methoxyphenyl]-N₄-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine; With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; isopropyl alcohol; at 40 ℃; for 7h; under 1875.19 Torr; Autoclave; Large scale;

With hydrogenchloride; In tetrahydrofuran; water; isopropyl alcohol; at 25 ℃; for 10h; Large scale;

DOI:10.1021/acs.oprd.8b00427

Reference yield: 71.0%

N-[4-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-methoxyphenyl]-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine (1097917-81-1) → 1-[3-methoxy-4-({4-[2-(propane-2-sulfonyl)anilino]-1,3,5-triazin-2-yl}amino)phenyl]piperidin-4-one (1097917-68-4)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; at 80 ℃; for 2h;

DOI:10.1248/cpb.c17-00784

upstream raw materials:

1-amino-2-(isopropylsulphonyl)benzene

4,4-dimethoxypiperidine monohydrochloride

4,6-dichloro-N-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazin-2-amine

4-fluoro-2-methoxy-1-nitrobenzene

Downstream raw materials:

N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)-piperidin-1-yl]phenyl}-N′-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine