EGT1442

Base Information

Chemical Name:EGT1442
CAS No.:1118567-05-7
Molecular Formula:C24H29ClO7
Molecular Weight:464.943
Hs Code.:
Mol file:1118567-05-7.mol

Synonyms:EGT1442;(1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-D-glucitol;Bexagliflozin

Suppliers and Price of EGT1442

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Bexagliflozin3
10mg
$ 310.00

DC Chemicals
Bexagliflozin(THR1442，EGT1442)| >98%
100 mg
$ 550.00

Crysdot
Bexagliflozin 98+%
100mg
$ 1026.00

Crysdot
Bexagliflozin 98+%
50mg
$ 673.00

Crysdot
Bexagliflozin 98+%
25mg
$ 455.00

Crysdot
Bexagliflozin 98+%
10mg
$ 228.00

ChemScene
Bexagliflozin 99.48%
100mg
$ 1068.00

ChemScene
Bexagliflozin 99.48%
2mg
$ 108.00

ChemScene
Bexagliflozin 99.48%
5mg
$ 156.00

ChemScene
Bexagliflozin 99.48%
10mg
$ 228.00

Total 48 raw suppliers

Chemical Property of EGT1442

Chemical Property:

Boiling Point:671.0±55.0 °C(Predicted)
PKA:13.23±0.70(Predicted)
PSA：108.61000
Density:1.41
LogP:2.00350

Purity/Quality:

99%, ^*data from raw suppliers

Bexagliflozin3 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description EGT-1442 is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 μM and 2 nM for human SGLT1 and SGLT2, respectively. It produces a stable urinary excretion of glucose in rats and dogs with ED50 values of 0.38 and 0.09 mg/kg, respectively, and reduces HbA(1c) and blood glucose in db/db mice in a concentration dependent manner.
Uses Bexagliflozin, also known as EGT1442, is a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats. EGT1442 showed favorable properties both in vitro and in vivo and could be beneficial to the management of type 2 diabetic patients.

Technology Process of EGT1442

There total 24 articles about EGT1442 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.9%

: (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, bis(L-proline) complex

: 1118567-05-7
(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Guidance literature:: In methanol; water; at 20 ℃; for 5h; Product distribution / selectivity;

Reference yield: 90.0%

: 1459754-30-3
(3R,4S,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol

: 1118567-05-7
(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; acetonitrile; at -25 - -20 ℃; for 4h; Temperature; Concentration; Inert atmosphere; Large scale;

Reference yield:

: 461432-22-4
(5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanone

: 1118567-05-7
(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylsilane; trifluorormethanesulfonic acid; trifluoroacetic acid / 20 °C / Reflux

2.1: n-butyllithium / tetrahydrofuran; toluene / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C

3.1: triethylsilane; boron trifluoride diethyl etherate / methanol; dichloromethane / 0 °C

4.1: boron tribromide / dichloromethane / -78 - 0 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With triethylsilane; n-butyllithium; trifluorormethanesulfonic acid; boron trifluoride diethyl etherate; boron tribromide; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;