5-Methoxy-2-(trifluoroMethyl)benzaldehyde

Base Information

• Chemical Name: 5-Methoxy-2-(trifluoroMethyl)benzaldehyde
• CAS No.: 944905-42-4
• Molecular Formula: C₉H₇F₃O₂
• Molecular Weight: 204.149
• Hs Code.: 2913000090
• Mol file: 944905-42-4.mol

Synonyms:CL9056;

Chemical Property of 5-Methoxy-2-(trifluoroMethyl)benzaldehyde

Chemical Property:

• Boiling Point: 254.315 °C at 760 mmHg
• Flash Point: 104.473 °C
• PSA: 26.30000
• Density: 1.287 g/cm³
• LogP: 2.52650
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-Methoxy-2-(trifluoromethyl)benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Methoxy-2-(trifluoroMethyl)benzaldehyde

There total 1 articles about 5-Methoxy-2-(trifluoroMethyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-(trifluoromethyl)phenyl ether (402-52-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-trifluoromethyl-5-methoxybenzaldehyde (944905-42-4)

Guidance literature:

methyl 4-(trifluoromethyl)phenyl ether; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 2h;

N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃;

Reference yield: 88.0%

2-thioxo-4-thiazolidinone (141-84-4) + 2-trifluoromethyl-5-methoxybenzaldehyde (944905-42-4) → 5-(5-methoxy-2-(trifluoromethyl)benzylidene)-2-thioxothiazolidin-4-one

Guidance literature:

With sodium hydroxide; In ethanol; Reflux;

DOI:10.1016/j.cclet.2014.10.008

Reference yield:

2-trifluoromethyl-5-methoxybenzaldehyde (944905-42-4) → 2-trifluoromethyl-N'-hydroxy-5-methoxybenzamidine

Guidance literature:

Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride / ethanol / 4 h / Reflux

2: trifluoromethyl acetic acid anhydride; triethylamine / tetrahydrofuran

3: sodium acetate; hydroxylamine hydrochloride / methanol; water / 12 h / Reflux

With trifluoromethyl acetic acid anhydride; hydroxylamine hydrochloride; sodium acetate; triethylamine; In tetrahydrofuran; methanol; ethanol; water;

upstream raw materials:

methyl 4-(trifluoromethyl)phenyl ether

N,N-dimethyl-formamide

Refernces