Synonyms:Rhodanine
99.9% *data from raw suppliers
Rhodanine *data from reagent suppliers
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There total 30 articles about Rhodanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
Reference yield: 94.0%
Reference yield: 83.0%
Reference yield: 77.0%
The research focuses on the identification, synthesis, and evaluation of selective small molecule inhibitors targeting human arylamine N-acetyltransferase 1 (NAT1) and its murine homologue, mouse arylamine N-acetyltransferase 2 (Nat2), which are potential markers for breast cancer. The study involves high-throughput screening of a 5000-member compound library against a panel of five different recombinant NAT proteins, including both mammalian and non-mammalian enzymes, to identify broad-spectrum inhibitors and those with specificity for individual NAT isoforms. The most potent inhibitors, identified as rhodanine and thiazolidin-2,4-dione derivatives, exhibit submicromolar activity and competitively inhibit both recombinant proteins and human NAT1 in ZR-75 cell lysates. The experiments utilized various assay methods, including the acetylation of arylamines and hydrolysis of AcCoA, to measure enzyme activity and inhibition. Additionally, 1H NMR studies were conducted on purified mouse Nat2 to confirm the binding of inhibitors within the enzyme's active site. The research also encompassed structure-activity relationship (SAR) analysis to optimize inhibitory activity and in silico modeling to predict the binding mode of the inhibitors to the protein. The compounds were further tested for cell-based toxicity to ensure their potential as non-toxic molecular tools for probing the role of human NAT1 and mouse Nat2 in cellular contexts.
The research is focused on the synthesis and evaluation of a new class of 2-(trifluoromethyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazole derivatives as potential antitubercular agents. The researchers synthesized these compounds using both conventional and microwave-assisted methods, and evaluated their in vitro antitubercular activity against M. tuberculosis H37Rv. The chemicals that played a role in the research include 5-(trifluoromethyl)-1,3,4-thiadiazol-2-amine, various substituted α-haloaryl ketones, thiazolidine-2,4-dione, 2-thioxothiazolidin-4-one (rhodanine), and 2-(4-oxo-2-thioxothiazolidin-3-yl)acetic acid (rhodanine acetic acid). The synthesized compounds were characterized by IR, NMR, mass spectra, and elemental analysis. The study found that several compounds exhibited good antitubercular activity, with some showing promising potential as lead scaffolds for the development of new anti-TB agents.
The study, titled "Synthesis of New Azocompounds and Fused Pyrazolo[5,1-c][1,2,4]triazines Using Heterocyclic Components," investigates the synthesis of new azocompounds and tricyclic pyrazolo[5,1-c][1,2,4]triazines using various heterocyclic components. The key chemical involved is 3-methyl-4-phenyl-1H-pyrazol-5-amine, which is diazotized to form pyrazole-3(5)-diazonium chloride. This diazonium salt undergoes azocoupling reactions with a variety of heterocyclic compounds, including barbituric acid, thiobarbituric acid, 2-hetarylpyrimidine-4,6-diones, 4-hydroxy-6-methylpyridin-2(1H)-one, 4-hydroxy-6-methyl-2H-pyran-2-one, 4-hydroxy-1-p-tolyl-1H-pyrazole-3-carboxylic acid ethyl ester, 1,3-thiazolidine-2,4-dione, and 2-thioxo-1,3-thiazolidin-4-one. These reactions yield new pyrazolylazo derivatives and fused pyrazolo[5,1-c][1,2,4]triazines through subsequent heterocyclization processes. The study explores the synthetic potential of these heterocyclic components in azocoupling reactions, highlighting their potential applications in industrial azo dyes, analytical indicators, and bioactive compounds related to purines.
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