Benzamide, 2-amino-3-fluoro- (9CI)

Base Information

• Chemical Name: Benzamide, 2-amino-3-fluoro- (9CI)
• CAS No.: 187805-54-5
• Molecular Formula: C7H7FN2O
• Molecular Weight: 154.144
• Mol file: 187805-54-5.mol

Synonyms:2-aMino-3-fluorobenzaMide;Benzamide, 2-amino-3-fluoro- (9CI);

Chemical Property of Benzamide, 2-amino-3-fluoro- (9CI)

Chemical Property:

• PSA: 70.10000
• LogP: 1.97220

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-3-fluorobenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzamide, 2-amino-3-fluoro- (9CI)

There total 4 articles about Benzamide, 2-amino-3-fluoro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

7-fluoro-1H-indole-2,3-dione (317-20-4) → 2-amino-3-fluorobenzamide (187805-54-5)

Guidance literature:

With sodium azide; sulfuric acid; isopropyl alcohol; at 27 ℃; for 4h;

DOI:10.1021/acs.joc.1c02036

Reference yield: 84.0%

3-fluoroanthranilic acid (825-22-9) → 2-amino-3-fluorobenzamide (187805-54-5)

Guidance literature:

With ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 6h; Inert atmosphere;

Reference yield: 45.0%

3-fluoroanthranilic acid (825-22-9) + benzotriazol-1-ol (2592-95-2) → 2-amino-3-fluorobenzamide (187805-54-5)

Guidance literature:

With ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

3-fluoroanthranilic acid

benzotriazol-1-ol

7-fluoro-1H-indole-2,3-dione

Downstream raw materials:

C₇H₆BrFN₂O

Refernces

• 1、 Qian, Peng,Liu, Jiaojiao,Zhang, Yan,Wang, Zhiyong. "Tunable Electrosynthesis of Anthranilic Acid Derivatives via a C-C Bond Cleavage of Isatins". . p. 16008 - 16015. Retrieved 2021/07/31.
• 2、 -. "POLY-ADP RIBOSE POLYMERASE (PARP) INHIBITORS". Page/Page column 61. . Retrieved 2018/07/29.