2,3-Dibromo-1,4-dimethoxybenzene

Base Information

• Chemical Name: 2,3-Dibromo-1,4-dimethoxybenzene
• CAS No.: 5030-61-5
• Molecular Formula: C8H8Br2O2
• Molecular Weight: 295.958
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID60564931
• Nikkaji Number: J2.917.374E
• Wikidata: Q82449818
• Mol file: 5030-61-5.mol

Synonyms:2,3-dibromo-1,4-dimethoxybenzene;5030-61-5;1,4-DIMETHOXY-2,3-DIBROMOBENZENE;MFCD11519213;SCHEMBL10398173;DTXSID60564931;2,3-dibromo-1,4-dimethoxy-benzene;AKOS022171954;DS-5530;SY116396;CS-0061897;A828058;2 pound not3-Dibromo-1 pound not4-dimethoxybenzene

Chemical Property of 2,3-Dibromo-1,4-dimethoxybenzene

Chemical Property:

• Melting Point: 154-158 °C
• Boiling Point: 296.5±35.0 °C(Predicted)
• PSA: 18.46000
• Density: 1.742±0.06 g/cm3(Predicted)
• LogP: 3.22880
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 295.88706
• Heavy Atom Count: 12
• Complexity: 127

Purity/Quality:

97% ^*data from raw suppliers

2,3-Dibromo-1,4-dimethoxybenzene 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C(=C(C=C1)OC)Br)Br

Technology Process of 2,3-Dibromo-1,4-dimethoxybenzene

There total 10 articles about 2,3-Dibromo-1,4-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2,3-dibromo-4-methoxyphenol (1266379-51-4) + methyl iodide (74-88-4) → 2,3-dibromo-1,4-dimethoxy benzene (5030-61-5)

Guidance literature:

With potassium carbonate; In acetone; for 18h; Reflux;

DOI:10.1002/ejoc.201001217

Reference yield:

2-(2,3-dibromo-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1266379-50-3) → 2,3-dibromo-1,4-dimethoxy benzene (5030-61-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0 - 25 °C / Inert atmosphere

2: potassium carbonate / acetone / 18 h / Reflux

With dihydrogen peroxide; potassium carbonate; sodium hydroxide; In tetrahydrofuran; water; acetone;

DOI:10.1002/ejoc.201001217

Reference yield:

2-(2,3-dibromo-4-iodophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1266379-46-7) → 2,3-dibromo-1,4-dimethoxy benzene (5030-61-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0 - 25 °C / Inert atmosphere

2.1: potassium carbonate / acetone / 18 h / Reflux

3.1: isopropylmagnesium chloride / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

3.2: -78 - 25 °C / Inert atmosphere

4.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 0 - 25 °C / Inert atmosphere

5.1: potassium carbonate / acetone / 18 h / Reflux

With dihydrogen peroxide; isopropylmagnesium chloride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; water; acetone;

DOI:10.1002/ejoc.201001217

upstream raw materials:

3,4-dibromo-2,5-dimethoxy-aniline

2,3-Dibrom-6-nitro-hydrochinon-dimethylaether

2,3-dibromo-4-methoxyphenol

methyl iodide

Downstream raw materials:

2,3-Dibromo-1,4-benzoquinone