2-Fluoro-3-iodo-benzonitrile

Base Information

• Chemical Name: 2-Fluoro-3-iodo-benzonitrile
• CAS No.: 211943-27-0
• Molecular Formula: C7H3FIN
• Molecular Weight: 247.01
• Hs Code.: 2926907090
• Mol file: 211943-27-0.mol

Synonyms:2-Fluoro-3-iodo-benzonitrile;Benzonitrile, 2-fluoro-3-iodo-

Chemical Property of 2-Fluoro-3-iodo-benzonitrile

Chemical Property:

• PSA: 23.79000
• LogP: 2.30198
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-3-iodobenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-3-iodo-benzonitrile

There total 1 articles about 2-Fluoro-3-iodo-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-fluorobenzonitrile (394-47-8) → 2-fluoro-3-iodobenzonitrile (211943-27-0)

Guidance literature:

2-fluorobenzonitrile; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

With iodine; In tetrahydrofuran; for 12h; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02572

Reference yield: 82.0%

2-fluoro-3-iodobenzonitrile (211943-27-0) → 2-fluoro-3-iodobenzoic acid (447464-03-1)

Guidance literature:

With sulfuric acid; water; In 1,4-dioxane; at 115 ℃; for 4h;

Reference yield:

2-fluoro-3-iodobenzonitrile (211943-27-0) + trimethylsilylacetylene (1066-54-2) → 3-ethynyl-2-fluorobenzonitrile

Guidance literature:

2-fluoro-3-iodobenzonitrile; trimethylsilylacetylene; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 30 ℃; for 2h;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 1.5h;

DOI:10.1002/anie.202008572

upstream raw materials:

2-fluorobenzonitrile

Downstream raw materials:

2-fluoro-3-iodobenzoic acid

2-fluoro-3-iodobenzaldehyde oxime

C₇H₄ClFINO

N-cyclopropyl-2-fluoro-N'-hydroxy-3-iodobenzimidamide

Refernces

• 1、 Dos Santos, Thiago,Orenha, Henrique P.,Murie, Valter E.,Vessecchi, Ricardo,Clososki, Giuliano C.. "Selective Metalation and Functionalization of Fluorinated Nitriles Using 2,2,6,6-Tetramethylpiperidyl Bases". supporting information. p. 7396 - 7400. Retrieved 2021/10/01.
• 2、 -. "New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors". Page/Page column 32. . Retrieved 2009/12/04.