2-Nitro-5-(trifluoromethyl)benzyl alcohol

Base Information

• Chemical Name: 2-Nitro-5-(trifluoromethyl)benzyl alcohol
• CAS No.: 1227604-33-2
• Molecular Formula: C8H6F3NO3
• Molecular Weight: 221.13
• Hs Code.: 2906290090
• Mol file: 1227604-33-2.mol

Synonyms:(2-Nitro-5-(trifluoromethyl)phenyl)methanol;2-Nitro-5-(trifluoromethyl)benzyl alcohol;

Chemical Property of 2-Nitro-5-(trifluoromethyl)benzyl alcohol

Chemical Property:

• PSA: 66.05000
• LogP: 2.62910
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Nitro-5-(trifluoromethyl)benzylAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Nitro-5-(trifluoromethyl)benzyl alcohol

There total 2 articles about 2-Nitro-5-(trifluoromethyl)benzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-nitro-5-(trifluoromethyl)benzaldehyde (1176723-57-1) → C8H6F3NO3 (1227604-33-2)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

DOI:10.1021/jo200530j

Reference yield:

2-methyl-4-trifluoromethylnitrobenzene (67192-42-1) → C8H6F3NO3 (1227604-33-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide dimethyl acetal / N,N-dimethyl-formamide / 24 h / 100 °C

1.2: 18 h / 20 °C

2.1: sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 - 20 °C

With sodium tetrahydroborate; N,N-dimethyl-formamide dimethyl acetal; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jo200530j

Reference yield: 79.0%

C8H6F3NO3 (1227604-33-2) → 2-(bromomethyl)-1-nitro-4-(trifluoromethyl)benzene (133605-28-4)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/jo200530j

upstream raw materials:

2-nitro-5-(trifluoromethyl)benzaldehyde

2-methyl-4-trifluoromethylnitrobenzene

Downstream raw materials:

tert-butyl N-(diphenylmethylidene)-2-nitro-5-(trifluoromethyl)-L-phenylalaninate

2-nitro-5-(trifluoromethyl)-L-phenylalanine

2-(bromomethyl)-1-nitro-4-(trifluoromethyl)benzene

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