O-(3,4-dichlorobenzyl)hydroxylaMine

Base Information

• Chemical Name: O-(3,4-dichlorobenzyl)hydroxylaMine
• CAS No.: 84772-12-3
• Molecular Formula: C7H7Cl2NO
• Molecular Weight: 192.045
• Mol file: 84772-12-3.mol

Synonyms:.(3,4-Dichlor-benzyloxy)-amin; O-(3,4-dichlorobenzyl)-hydroxylamine; 3,4–Dichlorobenzylhydroxylamine hydrochloride; .O-(3,4-Dichlor-benzyl)-hydroxylamin; .3,4-Dichlor-benzyloxyamin; .3,4-Dichlor-1-aminooxymethyl-benzol; 查看更多英文别名 收起

Chemical Property of O-(3,4-dichlorobenzyl)hydroxylaMine

Chemical Property:

• Vapor Pressure: 6.77E-05mmHg at 25°C
• Boiling Point: 339°C at 760 mmHg
• Flash Point: 158.8°C
• PSA: 35.25000
• LogP: 3.08400

Purity/Quality:

98%,99%, ^*data from raw suppliers

O-(3,4-dichlorobenzyl)hydroxylamine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of O-(3,4-dichlorobenzyl)hydroxylaMine

There total 9 articles about O-(3,4-dichlorobenzyl)hydroxylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.3%

2-(3,4-dichlorobenzyloxy)isoindole-1,3-dione (38936-82-2) → O-[(3,4-dichlorophenyl)methyl]hydroxylamine (84772-12-3)

Guidance literature:

With hydrazine hydrate; In ethanol; for 1h; Reflux;

DOI:10.1016/j.ejmech.2011.01.031

Reference yield: 75.0%

3,4-Dichlorophenylmethyl chloride (102-47-6) → O-[(3,4-dichlorophenyl)methyl]hydroxylamine (84772-12-3)

Guidance literature:

3,4-Dichlorophenylmethyl chloride; With ethyl N-hydroxylcarbamate; sodium ethanolate; In ethanol; at 20 ℃; for 10h;

With water; sodium hydroxide; In ethanol; for 2h; Reflux;

DOI:10.1016/j.tet.2020.131886

Reference yield:

3,4-dichlorobenzyl alcohol (1805-32-9) → O-[(3,4-dichlorophenyl)methyl]hydroxylamine (84772-12-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

2: hydrazine hydrate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; hydrazine hydrate; triphenylphosphine; In tetrahydrofuran; 1: |Mitsunobu Displacement;

DOI:10.1016/j.ejmech.2015.12.028

upstream raw materials:

N-(3,4-Dichlor-benzyloxy)-carbamidsaeure-ethylester

Benzhydroxamsaeure-<3.4-dichlor-benzylaether>

3,4-Dichlorophenylmethyl chloride

2-(2,3-Dichloro-benzyloxy)-isoindole-1,3-dione

Downstream raw materials:

N-<4-Chlor-benzyl>-N'-<3,4-dichlor-benzyloxy>-thioharnstoff

N-<3,4-Dichlor-benzyl>-N'-<3,4-dichlor-benzyloxy>-thioharnstoff

3-(3,4-Dichloro-benzyloxyamino)-propionic acid methyl ester

4,5-dibromo-1H-pyrrole-2-carboxylic acid (3,4-dichlorobenzyloxy)amide