[(3,4-Dichlorophenyl)methoxy]ammonium chloride

Base Information

• Chemical Name: [(3,4-Dichlorophenyl)methoxy]ammonium chloride
• CAS No.: 15256-10-7
• Molecular Formula: C7H7 Cl2 N O . Cl H
• Molecular Weight: 228.506
• Hs Code.: 2922199090
• DSSTox Substance ID: DTXSID30377252
• Mol file: 15256-10-7.mol

Synonyms:(3,4-dichlorophenyl)methoxyazanium;chloride;DTXSID30377252;[(3,4-Dichlorophenyl)methoxy]ammonium chloride;O-(3,4-Dichlorobenzyl)hydroxylaminehydrochloride

Chemical Property of [(3,4-Dichlorophenyl)methoxy]ammonium chloride

Chemical Property:

• Vapor Pressure: 6.77E-05mmHg at 25°C
• Melting Point: 195oC
• Boiling Point: 339°Cat760mmHg
• Flash Point: 158.8°C
• PSA: 35.25000
• Density: g/cm³
• LogP: 3.88600
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly, Heated)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 226.967147
• Heavy Atom Count: 12
• Complexity: 123

Purity/Quality:

99% ^*data from raw suppliers

4-[(Aminooxy)methyl]-1,2-dichlorobenzenehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1CO[NH3+])Cl)Cl.[Cl-]
• Uses: 4-[(Aminooxy)methyl]-1,2-dichlorobenzenehydrochloride, has shown to act as inhibitor of indoleamine 2,3-dioxygenase-1. ndoleamine 2,3-dioxygenase-1 (IDO1) is a promising therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterized by pathol.

Technology Process of [(3,4-Dichlorophenyl)methoxy]ammonium chloride

There total 7 articles about [(3,4-Dichlorophenyl)methoxy]ammonium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3,4-dichlorobenzyloxy)isoindole-1,3-dione (38936-82-2) → 4-((ammoniooxy)methyl)-1,2-dichlorobenzene chloride (15256-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2: hydrogenchloride / diethyl ether / Inert atmosphere

With hydrogenchloride; hydrazine hydrate; In tetrahydrofuran; diethyl ether;

DOI:10.1016/j.ejmech.2015.12.028

Reference yield:

O-[(3,4-dichlorophenyl)methyl]hydroxylamine (84772-12-3) → 4-((ammoniooxy)methyl)-1,2-dichlorobenzene chloride (15256-10-7)

Guidance literature:

With hydrogenchloride; In diethyl ether; Inert atmosphere;

DOI:10.1016/j.ejmech.2015.12.028

Reference yield:

N-(3,4-dichloro-benzyloxy)-acetamide → 4-((ammoniooxy)methyl)-1,2-dichlorobenzene chloride (15256-10-7)

Guidance literature:

With hydrogenchloride; In methanol; for 24h;

DOI:10.1021/jm010089z

upstream raw materials:

3,4-Dichlorophenylmethyl chloride

3,4-dichlorobenzyl alcohol

3,4-dichlorobenzaldehyde

O-[(3,4-dichlorophenyl)methyl]hydroxylamine

Downstream raw materials:

4-(3,4-Dichlor-benzyloxy)-allophansaeure-(3,4-dichlor-benzylester)

tert-butyl N-(3,4-dichlorobenzyloxy)carbamate

C₁₅H₁₀Cl₃F₃N₂O₃S

C₂₁H₁₄Cl₃F₃N₂O₃S

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