5-BroMo-2',3',5'-tri-O-t-butyldiMethylsilyluridine

Base Information

Chemical Name:5-BroMo-2',3',5'-tri-O-t-butyldiMethylsilyluridine
CAS No.:122699-13-2
Molecular Formula:C27H53BrN2O6Si3
Molecular Weight:549.57094
Hs Code.:
Mol file:122699-13-2.mol

Synonyms:5-bromo-2',3',5'-tri-O-(tert-butyldimethylsilyl)uridine;1-[(2R,3R,4R,5R)-3,4-Bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-bromo-1H-pyrimidine-2,4-dione;

Suppliers and Price of 5-BroMo-2',3',5'-tri-O-t-butyldiMethylsilyluridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-BroMo-2',3',5'-tri-O-t-butyldiMethylsilyluridine

Chemical Property:

PSA：91.78000
LogP:6.99910

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 5-BroMo-2',3',5'-tri-O-t-butyldiMethylsilyluridine

There total 3 articles about 5-BroMo-2',3',5'-tri-O-t-butyldiMethylsilyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 957-75-5
5-bromouridine

: 18162-48-6
tert-butyldimethylsilyl chloride

: 122699-13-2
5-bromo-2',3',5'-tri-O-(tert-butyldimethylsilyl)uridine

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;
DOI:10.1002/chem.200900397

Reference yield: 83.0%

: 64898-15-3
2',3',5'-tris-O-(tert-butyldimethylsilyl)uridine

: 122699-13-2
5-bromo-2',3',5'-tri-O-(tert-butyldimethylsilyl)uridine

Guidance literature:: With sodium hydrogencarbonate; lithium bromide; In acetonitrile; Ambient temperature; electrolysis (Pt electrodes, SCE reference, LiClO₄ as supporting electrolyte);
DOI:10.1016/0040-4039(93)88044-J

Reference yield:

: 58-96-8
uridine

: 122699-13-2
5-bromo-2',3',5'-tri-O-(tert-butyldimethylsilyl)uridine

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / N,N-dimethyl-formamide / 4 h / 80 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

With 1H-imidazole; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In N,N-dimethyl-formamide;