Technology Process of N3-benzoyl-2',3',5'-tri-O-acetyluridine-5-malonic acid dimethyl ester
There total 4 articles about N3-benzoyl-2',3',5'-tri-O-acetyluridine-5-malonic acid dimethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran;
at 20 ℃;
DOI:10.1002/anie.201001242
- Guidance literature:
-
Multi-step reaction with 3 steps
1: acetic anhydride; acetic acid; bromine / 0 - 20 °C
2: dmap; triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 °C
With
dmap; bromine; acetic anhydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: pyridine / 3 h / 60 °C
2: acetic anhydride; acetic acid; bromine / 0 - 20 °C
3: dmap; triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
4: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 °C
With
pyridine; dmap; bromine; acetic anhydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine;
In
tetrahydrofuran; dichloromethane;
