2',3',5'-Tri-O-acetyl-5-hydroxymethyl uridine

Base Information

Chemical Name:2',3',5'-Tri-O-acetyl-5-hydroxymethyl uridine
CAS No.:285549-57-7
Molecular Formula:C16H20N2O10
Molecular Weight:400.342
Hs Code.:
Mol file:285549-57-7.mol

Synonyms:5-(Hydroxymethyl)uridine 2',3',5'-triacetate;5-(hydroxymethyl)-2',3',5'-triacetateuridine;2',3',5'-Tri-O-acetyl-5-hydroxyMethyl uridine;Uridine, 5-(hydroxymethyl)-, 2',3',5'-triacetate

Suppliers and Price of 2',3',5'-Tri-O-acetyl-5-hydroxymethyl uridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of 2',3',5'-Tri-O-acetyl-5-hydroxymethyl uridine

Chemical Property:

PKA:9.01±0.10(Predicted)
PSA：163.22000
Density:1.47±0.1 g/cm3(Predicted)
LogP:-1.64720

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2',3',5'-Tri-O-acetyl-5-hydroxymethyl uridine

There total 4 articles about 2',3',5'-Tri-O-acetyl-5-hydroxymethyl uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 4433-40-3
5-hydroxymethyl uracil

: 13035-61-5
1,2,3,5-tetraacetylribose

: 285549-57-7
2′,3′,5′-tri-O-acetyl-5-hydroxymethyluridine

Guidance literature:: With benzenesulfonamide; trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 75 ℃; for 2h;
DOI:10.1021/ol005797d

Reference yield: 69.0%

: 4433-40-3
5-hydroxymethyl uracil

: 194474-73-2
2′,3′,5′-tri-O-acetyl-5-nitrouridine

: 285549-57-7
2′,3′,5′-tri-O-acetyl-5-hydroxymethyluridine

Guidance literature:: 5-hydroxymethyl uracil; 2′,3′,5′-tri-O-acetyl-5-nitrouridine; With N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile; at 20 ℃; for 1h; Microwave irradiation;

With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 80 ℃; for 2h; Microwave irradiation; Sealed tube;
DOI:10.1021/acs.orglett.0c01941

Reference yield:

: 4105-38-8
Tri-O-acetyluridine

: 285549-57-7
2′,3′,5′-tri-O-acetyl-5-hydroxymethyluridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 1 h / 20 °C / Microwave irradiation

1.2: 1 h / 80 °C / Microwave irradiation; Sealed tube

2.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 1 h / 20 °C / Microwave irradiation

2.2: 2 h / 80 °C / Microwave irradiation; Sealed tube

With N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile;
DOI:10.1021/acs.orglett.0c01941