(R)-3-(1-Methylethyl)-Morpholine HCl

Base Information

• Chemical Name: (R)-3-(1-Methylethyl)-Morpholine HCl
• CAS No.: 1227917-52-3
• Molecular Formula: C₇H₁₅NO*ClH
• Molecular Weight: 165.663
• Hs Code.: 2934999090
• Mol file: 1227917-52-3.mol

Synonyms:(R)-3-(1-Methylethyl)-Morpholine HCl;

Chemical Property of (R)-3-(1-Methylethyl)-Morpholine HCl

Chemical Property:

• PSA: 21.26000
• LogP: 1.76160

Purity/Quality:

97% ^*data from raw suppliers

(R)-3-Isopropylmorpholinehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-(1-Methylethyl)-Morpholine HCl

There total 1 articles about (R)-3-(1-Methylethyl)-Morpholine HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-amino-3-methylbutanol (4276-09-9,473-75-6) → C7H15NO*ClH (1227917-52-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C

2.1: triethylamine / tetrahydrofuran / 1 h

3.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

4.1: lithium borohydride; chloro-trimethyl-silane / tetrahydrofuran / 1 h / 20 °C

5.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 6 h / 80 °C

5.2: 1 h / Reflux

With sodium tetrahydroborate; lithium borohydride; chloro-trimethyl-silane; carbonochloridic acid 1-chloro-ethyl ester; sodium hydride; triethylamine; In tetrahydrofuran; methanol; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2015.01.005

upstream raw materials:

(R)-2-amino-3-methylbutanol