3-Bromo-4-trifluoromethoxyanisole

Base Information

• Chemical Name: 3-Bromo-4-trifluoromethoxyanisole
• CAS No.: 1049730-91-7
• Molecular Formula: C8H6BrF3O2
• Molecular Weight: 271.034
• Hs Code.: 2909309090
• Mol file: 1049730-91-7.mol

Synonyms:2-Bromo-4-methoxy-1-(trifluoromethoxy)benzene;

Chemical Property of 3-Bromo-4-trifluoromethoxyanisole

Chemical Property:

• PSA: 18.46000
• LogP: 3.35630
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromo-4-methoxy-1-(trifluoromethoxy)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-4-trifluoromethoxyanisole

There total 1 articles about 3-Bromo-4-trifluoromethoxyanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-bromo-4-(trifluoromethoxy)phenol (886496-88-4) + methyl iodide (74-88-4) → 2-bromo-4-methoxy-1-(trifluoromethoxy)benzene (1049730-91-7)

Guidance literature:

With potassium carbonate; In acetone; for 10h;

Reference yield: 43.0%

2-bromo-4-methoxy-1-(trifluoromethoxy)benzene (1049730-91-7) → 5-methoxy-2-(trifluoromethoxy)-phenylboronic acid (1079402-25-7)

Guidance literature:

2-bromo-4-methoxy-1-(trifluoromethoxy)benzene; With n-butyllithium; In tetrahydrofuran; hexanes; at -70 ℃; for 1h;

With Triisopropyl borate; In tetrahydrofuran; hexanes; at -70 ℃; for 2h;

With hydrogenchloride; water; In tetrahydrofuran; hexanes; pH=~ 5;

Reference yield:

2-bromo-4-methoxy-1-(trifluoromethoxy)benzene (1049730-91-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-methoxy-2-(trifluoromethoxy)benzaldehyde

Guidance literature:

2-bromo-4-methoxy-1-(trifluoromethoxy)benzene; With n-butyllithium; In tetrahydrofuran; at -60 ℃;

N,N-dimethyl-formamide; In tetrahydrofuran; at -60 - 20 ℃; for 1h;

upstream raw materials:

3-bromo-4-(trifluoromethoxy)phenol

methyl iodide

Downstream raw materials:

5-methoxy-2-(trifluoromethoxy)-phenylboronic acid

Refernces

• 1、 -. "Therapeutic Compounds and Their Use in Treating Diseases and Disorders". Page/Page column 67. . Retrieved 2009/06/27.