(2S,4S)-4-(Acetylthio)-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester

Base Information

Chemical Name:(2S,4S)-4-(Acetylthio)-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester
CAS No.:104773-40-2
Molecular Formula:C15H18N2O6S
Molecular Weight:354.384
Hs Code.:
Mol file:104773-40-2.mol

Synonyms:(2S,4S)-4-(Acetylthio)-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester

Suppliers and Price of (2S,4S)-4-(Acetylthio)-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 22 raw suppliers

Chemical Property of (2S,4S)-4-(Acetylthio)-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester

Chemical Property:

Melting Point:128 - 130 °C
PSA：137.96000
Density:1.41
LogP:2.40740

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S,4S)-4-(Acetylthio)-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester

There total 10 articles about (2S,4S)-4-(Acetylthio)-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 127626-37-3
(2S,4R)-2-hydroxymethyl-4-methanesulfonyloxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine

: 10387-40-3
potassium thioacetate

: 104773-40-2
(2S,4S)-4-acetylthio-2-hydroxymethyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine

Guidance literature:: In acetonitrile; for 8h; Heating;
DOI:10.1016/j.ejmech.2006.08.003

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 104773-40-2
(2S,4S)-4-acetylthio-2-hydroxymethyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / triethylamine / CH₂Cl₂ / 2 h

2: 88 percent / triethylamine / CH₂Cl₂ / 3 h / 0 °C

3: 80 percent / lithium chloride; sodium borohydride / tetrahydrofuran; ethanol / 4 h / 20 °C

4: 81 percent / acetonitrile / 8 h / Heating

With sodium tetrahydroborate; triethylamine; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.ejmech.2006.08.003