127626-37-3

Basic information

• Product Name: (2S,4R)-2-(Hydroxymethyl)-4-[(methylsulfonyl)oxy]-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester
• Synonyms: (2S,4R)-2-(Hydroxymethyl)-4-[(methylsulfonyl)oxy]-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester;(2S,4R)-2-(hydroxyMethyl)-4-[(Methylsulfonyl)oxy]-1-Pyrrolidinecarboxylic acid,(4-nitrophenyl)Methyl ester (DoripeneM side-chain interMediate);DoripeneM InterMediates;(2S,trans)-4-Nitrobenzyl 2-(hydroxymethyl)-4-((methylsulfonyl)oxy)pyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-4-[(methylsulfonyl)oxy]-, (4-nitrophenyl)methyl ester, (2S,4R)-;(4-nitrophenyl)methyl (2S,4R)-2-(hydroxymethyl)-4-methylsulfonyloxypyrrolidine-1-carboxylate
• CAS NO: 127626-37-3
• Molecular Formula: C₁₄H₁₈N₂O₈S
• Molecular Weight: 374.36632
• EINECS: 1533716-785-6
• Product Categories: Doripenem Intermediate
• Mol File: 127626-37-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 113-116℃
• Boiling Point: 619.8 °C at 760 mmHg
• Flash Point: 328.6 °C
• Appearance: /
• Density: 1.51
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (2S,4R)-2-(Hydroxymethyl)-4-[(methylsulfonyl)oxy]-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-2-(Hydroxymethyl)-4-[(methylsulfonyl)oxy]-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester(127626-37-3)
• EPA Substance Registry System: (2S,4R)-2-(Hydroxymethyl)-4-[(methylsulfonyl)oxy]-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester(127626-37-3)

Safety Data

• Hazardous Substances Data: 127626-37-3(Hazardous Substances Data)

Usage

General Description

The chemical "(2S,4R)-2-(Hydroxymethyl)-4-[(methylsulfonyl)oxy]-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester" is a compound with a pyrrolidine ring structure, containing a hydroxymethyl and a methylsulfonyloxy group. It also has a 4-nitrophenylmethyl ester which is a type of ester formed from the reaction of 4-nitrophenol and methyl alcohol. (2S,4R)-2-(Hydroxymethyl)-4-[(methylsulfonyl)oxy]-1-pyrrolidinecarboxylic acid (4-nitrophenyl)methyl ester is frequently used in chemical and pharmaceutical research due to its involvement in the synthesis of various organic compounds. It may have potential uses in drug development and medicinal chemistry as a building block or precursor for the synthesis of biologically active compounds. However, it's important to note that this chemical should be handled carefully and with proper safety precautions due to its potential reactivity and toxicity.

Upstream product

• 96034-57-0 (2S,4R)-4-Hydroxy-1-(4-nitrobenzyloxycarbonyl)pyrrolidine-2-carboxylic acid 
• 138324-82-0 (2S,4R)-4-mesyloxy-1-(p-nitrobenzyloxycarbonyl)pyrrolidine-2-carboxylic acid methyl ester 
• 4457-32-3 4-nitrobenzyl chloroformate 
• 51-35-4 4R-4-hydroxyproline 
• 101803-29-6 (2S,4R)-4-hydroxy-2-methoxycarbonyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 

Downstream Products

• 491878-06-9 (2S,4S)-4-acetylthio-2-[[N-aminosulfonyl-N-(tert-butyloxycarbonyl)amino]methyl]pyrrolidine-1-carboxylic acid p-nitrobenzyl ester 
• 101803-42-3 (2S,4S)-4-mercapto-2-hydroxymethyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 104773-40-2 (2S,4S)-4-acetylthio-2-hydroxymethyl-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 

Relevant articles and documents

Synthesis and?antibacterial activities of?new 1β-methylcarbapenems having aminopyrimidinylthioether moiety

The synthesis of new 1β-methylcarbapenems 1a-d bearing aminopyrimidinylthioether moiety at C-5 position of pyrrolidine ring and their antibacterial activities are described. All the compounds exhibited potent antibacterial activity. Of these carbapenems, 1d showed the best combination of antibacterial activity and stability to dehydropeptidase-I (DHP-I).

Pyrrolidylthiocarbapenem derivative

A pyrrolidylthiocarbapenem derivative represented by Formula I is provided: STR1 wherein R1 is hydrogen or lower alkyl; R2, R3 and R4 are hydrogen, lower alkyl which can be substituted or an amino protecting group independently, or R2 and R3 together with a nitrogen atom to which R2 and R3 are bonded form a saturated or unsaturated cyclic group, or R2 and R4, or R3 and R4 together with two nitrogen atoms and one sulfur atom in the sufamide group form a saturated or unsaturated cyclic group; each cyclic group can further include at least one atom selected from the group consisting of oxygen, sulfur and nitrogen, and each cyclic group can be substituted; X1 is hydrogen or a hydroxy protecting group; X2 is hydrogen, a carboxy protecting group, an ammonio group, an alkali metal or an alkaline-earth metal; and Y2 is hydrogen or an amino protecting group.