Ethyl 3-benzyl-9-((S)-1-phenylethyl)-7-(tosyloxy)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylate

Base Information

Chemical Name:Ethyl 3-benzyl-9-((S)-1-phenylethyl)-7-(tosyloxy)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylate
CAS No.:1041439-31-9
Molecular Formula:C32H36N2O5S
Molecular Weight:560.7
Hs Code.:
Mol file:1041439-31-9.mol

Synonyms:ethyl 3-benzyl-9-((S)-1-phenylethyl)-7-(tosyloxy)-3,9-diazabicyclo3.3.1non-6-ene-6-carboxylate;

Suppliers and Price of Ethyl 3-benzyl-9-((S)-1-phenylethyl)-7-(tosyloxy)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ETHYL-3-BENZYL-9-((S)-1-PHENYLETHYL)-7-(TOSYLOXY)-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE-6-CARBOXYLATE 95.00%
10G
$ 2338.88

American Custom Chemicals Corporation
ETHYL-3-BENZYL-9-((S)-1-PHENYLETHYL)-7-(TOSYLOXY)-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE-6-CARBOXYLATE 95.00%
1G
$ 1143.45

Total 2 raw suppliers

Chemical Property of Ethyl 3-benzyl-9-((S)-1-phenylethyl)-7-(tosyloxy)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylate

Chemical Property:

Boiling Point:676.4±55.0 °C(Predicted)
PKA:4.98±0.60(Predicted)
PSA：84.53000
Density:1.29±0.1 g/cm3(Predicted)
LogP:6.19400

Purity/Quality:

98%min ^*data from raw suppliers

ETHYL-3-BENZYL-9-((S)-1-PHENYLETHYL)-7-(TOSYLOXY)-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE-6-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Ethyl 3-benzyl-9-((S)-1-phenylethyl)-7-(tosyloxy)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylate

There total 2 articles about Ethyl 3-benzyl-9-((S)-1-phenylethyl)-7-(tosyloxy)-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 3-benzyl-7-{[(4-methylphenyl)sulfonyl]oxy}-9-[(1R)-1-phenylethyl]-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylate bis methanesulfonic acid salt

: 1041439-31-9
ethyl 3-benzyl-7-{[(4-methylphenyl)sulfonyl]oxy}-9-[(1R)-1-phenylethyl]-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylate

Guidance literature:: With sodium hydroxide; In tert-butyl methyl ether; water; ethyl acetate; at 20 ℃; for 0.166667h; Inert atmosphere;
DOI:10.1021/ol102131e

Reference yield:

: 1041439-30-8
diethyl 2,2'-{cis-4-benzyl-1-[(1R)-1-phenylethyl]piperazine-2,6-diyl}diacetate

: 4124-41-8
p-toluenesulfonylanhydride

: 1041439-31-9
ethyl 3-benzyl-7-{[(4-methylphenyl)sulfonyl]oxy}-9-[(1R)-1-phenylethyl]-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylate

: ethyl 3-benzyl-7-{[(4-methylphenyl)sulfonyl]oxy}-9-[(1R)-1-phenylethyl]-3,9-diazabicyclo[3.3.1]non-6-ene-6-carboxylate

Guidance literature:: diethyl 2,2'-{cis-4-benzyl-1-[(1R)-1-phenylethyl]piperazine-2,6-diyl}diacetate; With potassium 2-methylbutan-2-olate; In N,N-dimethyl-formamide; toluene; at -25 - -5 ℃; for 2.75h; Inert atmosphere;

p-toluenesulfonylanhydride; With 2,6-di-tert-butyl-4-methyl-phenol; In N,N-dimethyl-formamide; toluene; acetonitrile; at 0 - 10 ℃; for 1h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol102131e