diethyl 2,2'-{cis-4-benzyl-1-[(1R)-1-phenylethyl]piperazine-2,6-diyl}diacetate

Base Information

Chemical Name:diethyl 2,2'-{cis-4-benzyl-1-[(1R)-1-phenylethyl]piperazine-2,6-diyl}diacetate
CAS No.:1041439-30-8
Molecular Formula:C₂₇H₃₆N₂O₄
Molecular Weight:452.594
Hs Code.:

Synonyms:diethyl 2,2'-{cis-4-benzyl-1-[(1R)-1-phenylethyl]piperazine-2,6-diyl}diacetate

Suppliers and Price of diethyl 2,2'-{cis-4-benzyl-1-[(1R)-1-phenylethyl]piperazine-2,6-diyl}diacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 2,2'-{cis-4-benzyl-1-[(1R)-1-phenylethyl]piperazine-2,6-diyl}diacetate

Chemical Property:

Boiling Point:527.6±35.0 °C(Predicted)
Density:1.102±0.06 g/cm3(Predicted)

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of diethyl 2,2'-{cis-4-benzyl-1-[(1R)-1-phenylethyl]piperazine-2,6-diyl}diacetate

There total 2 articles about diethyl 2,2'-{cis-4-benzyl-1-[(1R)-1-phenylethyl]piperazine-2,6-diyl}diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: diethyl (2E)-4,4'-(benzylimino)bisbut-2-enoate

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1041439-30-8
diethyl 2,2'-{cis-4-benzyl-1-[(1R)-1-phenylethyl]piperazine-2,6-diyl}diacetate

Guidance literature:: With 2,2,2-trifluoroethanol; at 80 ℃; for 12h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/ol102131e

Reference yield:

: 1041439-28-4
4-[benzyl-(3-ethoxycarbonylallyl)amino]but-2-enoic acid ethyl ester

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1041439-30-8
diethyl 2,2'-{cis-4-benzyl-1-[(1R)-1-phenylethyl]piperazine-2,6-diyl}diacetate

Guidance literature:: In 2,2,2-trifluoroethanol; for 10h; Heating / reflux;

Reference yield: 67.0%

: 75-75-2,98527-29-8
methanesulfonic acid

: 1041439-30-8
diethyl 2,2'-{cis-4-benzyl-1-[(1R)-1-phenylethyl]piperazine-2,6-diyl}diacetate

: 4124-41-8
p-toluenesulfonylanhydride

: 2CH₄O₃S*C₃₂H₃₆N₂O₅S

Guidance literature:: diethyl 2,2'-{cis-4-benzyl-1-[(1R)-1-phenylethyl]piperazine-2,6-diyl}diacetate; With potassium 2-methylbutan-2-olate; In N,N-dimethyl-formamide; toluene; at -25 - -5 ℃; for 2.75h;

p-toluenesulfonylanhydride; With 2,6-di-tert-butyl-4-methyl-phenol; In N,N-dimethyl-formamide; toluene; at 0 - 10 ℃; for 1.16667h;

methanesulfonic acid; In Isopropyl acetate; for 20h;