5-Methyl-d3-uridine-6-d1

Base Information

Chemical Name:5-Methyl-d3-uridine-6-d1
CAS No.:82845-85-0
Molecular Formula:C₁₀H₁₄N₂O₆
Molecular Weight:266.167
Hs Code.:
Mol file:82845-85-0.mol

Synonyms:5-METHYL-D3-URIDINE-6-D1;5-Methyl Uridine-d4;1-β-D-RibofuranosylthyMine-d4

Suppliers and Price of 5-Methyl-d3-uridine-6-d1

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Methyluridine-d4
25mg
$ 1230.00

American Custom Chemicals Corporation
5-METHYLURIDINE-D4 95.00%
2.5MG
$ 704.00

Total 6 raw suppliers

Chemical Property of 5-Methyl-d3-uridine-6-d1

Chemical Property:

PSA：124.78000
LogP:-2.54350

Purity/Quality:

95% by HPLC; 98% atom D ^*data from raw suppliers

5-Methyluridine-d4 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Labelled 5-Methyl Uridine. A primary degradation product of tRNA, Labelled 5-Methyl Uridine. A primary degradation product of tRNA, an urinary nucleoside as biological marker for patients with colorectal cancer.

Technology Process of 5-Methyl-d3-uridine-6-d1

There total 7 articles about 5-Methyl-d3-uridine-6-d1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-((2,3',5'-tri-O-acetyl)-β-D-ribofuranosyl)thymine-d₈

: 82845-85-0
1-(β-D-ribofuranosyl)thymine-d₈

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 64h;
DOI:10.1016/j.tetlet.2019.151037

Reference yield:

: 156054-85-2
thymine-α,α,α,6-d4

: 82845-85-0
1-(β-D-ribofuranosyl)thymine-d₈

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 20 °C / Inert atmosphere

1.2: 15 h / 60 °C / Inert atmosphere

2.1: ammonia / methanol / 64 h / 20 °C

With N,O-bis-(trimethylsilyl)-acetamide; ammonia; In methanol; acetonitrile;
DOI:10.1016/j.tetlet.2019.151037

Reference yield:

: 1824-96-0,1824-97-1,3795-68-4,3795-69-5,4229-54-3,5531-18-0,7473-45-2,13039-63-9,13039-64-0,13039-65-1,13039-67-3,22416-73-5,22861-09-2,25129-51-5,52485-92-4,52689-55-1,52689-56-2,56607-40-0,72880-70-7,79083-42-4,86782-30-1,86782-31-2,89615-03-2,89673-67-6,89707-99-3,102045-32-9,135910-17-7
methyl ribofuranoside

: 82845-85-0
1-(β-D-ribofuranosyl)thymine-d₈

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen; sodium hydroxide; water-d2; 10% Ru/C / 80 °C

2.1: pyridine

3.1: sulfuric acid / acetic acid / 3.5 h / 20 °C

4.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 20 °C / Inert atmosphere

4.2: 15 h / 60 °C / Inert atmosphere

5.1: ammonia / methanol / 64 h / 20 °C

With pyridine; N,O-bis-(trimethylsilyl)-acetamide; sulfuric acid; 10% Ru/C; ammonia; hydrogen; water-d2; sodium hydroxide; In methanol; acetic acid; acetonitrile;
DOI:10.1016/j.tetlet.2019.151037