156054-85-2

Usage

Uses

Used in Research Applications:
THYMINE-METHYL-D3-6-D is used as a research compound for studying the structure, function, and dynamics of DNA and RNA molecules. The incorporation of deuterium atoms allows for the investigation of molecular interactions, such as hydrogen bonding and base pairing, which are crucial for understanding the stability and integrity of genetic material.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, THYMINE-METHYL-D3-6-D is used as a building block for the synthesis of various nucleoside analogs and antiviral drugs. These analogs can be designed to target specific viral enzymes or reverse transcriptase, leading to the development of novel therapeutic agents for the treatment of viral infections.
Used in Diagnostic Applications:
THYMINE-METHYL-D3-6-D can be employed in the development of diagnostic tools and assays, such as those based on mass spectrometry or nuclear magnetic resonance (NMR) spectroscopy. The unique isotopic signature of the compound enables the detection and quantification of specific molecular species, which can be useful in the identification of disease biomarkers or the monitoring of drug metabolism.
Used in Biotechnology Applications:
In the field of biotechnology, THYMINE-METHYL-D3-6-D can be utilized for the development of novel genetic engineering techniques and the creation of modified organisms with enhanced properties. The isotopically labeled compound can be incorporated into DNA during in vitro manipulation, allowing for the tracking and analysis of specific genetic sequences or the study of epigenetic modifications, such as DNA methylation.

InChI:InChI=1/C5H6N2O2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)/i1D3,2D

Upstream product

• 65-71-4 thymin 

Downstream Products

• 82845-85-0 1-(β-D-ribofuranosyl)thymine-d₈ 

Relevant academic research and scientific papers

Palladium-catalyzed base-selective H-D exchange reaction of nucleosides in deuterium oxide

We have developed an efficient and extensive deuterium incorporation method using a heterogeneous Pd/C-D2O-H2 system into the base moiety of nucleosides. The results presented here provide a deuterium gas-free, totally catalytic, and post-synthetic deuterium labeling method in D 2O media. Georg Thieme Verlag Stuttgart.

Synthesis of the deuterated thymidine-d9 and deuterated oligonucleotides

The efficient synthesis of the highly-deuterated thymidine-d9 by the glycosylation reaction between a deuterated nucleobase and deuterated sugar is described. It is also incorporated into the oligonucleotides using a DNA synthesizer. Using this

Diphenylamino pyrimidine compound for inhibiting kinase activity

The invention provides a diphenylamino pyrimidine compound for inhibiting the kinase activity, and particularly provides a medicinal composition of a substituted diphenylamino pyrimidine compound andapplication thereof. The compound is a compound as shown in a formula (I) in the specification, or pharmaceutically acceptable salt, prodrug, hydrate thereof or solvent compound, crystal form, N-oxideand various diastereomers thereof. The compound can be used for treating diseases which can be treated with JAK2 kinase inhibitors.

METHOD FOR DEUTERATION OR TRITIATION OF HETEROCYCLIC RING

The present invention relates to a method for deuteration of a heterocyclic ring, which comprises subjecting a compound having a heterocyclic ring to sealed refluxing state in a deuterated solvent in the presence of an activated catalyst selected form a palladium catalyst, a platinum catalyst, a rhodium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst. In accordance with a method of the present invention, a hydrogen atom belonging to a heterocyclic ring of a compound having a heterocyclic ring can be very efficiently deuterated because temperature of deuteration reaction can be maintained at higher than boiling point of the solvent. Further, a method for deuteration of the present invention can be applied widely to deuteration of various compounds having a heterocyclic ring which are liable to decomposition under supercritical conditions or acidic conditions, leading to industrial and efficient deuteration of a compound having a heterocyclic ring.

Synthesis of base-selectively deuterium-labelled nucleosides by the Pd/C-catalyzed H-D exchange reaction in deuterium oxide

The D2 gas-free and base-selective H-D exchange reaction of nucleosides was developed. It discloses a convenient route to the post-synthetic incorporation of deuteriums into the base moiety of nucleic acids with high deuterium efficiency.