2-(2-Fluorophenoxy)ethylamine

Base Information

• Chemical Name: 2-(2-Fluorophenoxy)ethylamine
• CAS No.: 120351-90-8
• Molecular Formula: C8H10 F N O
• Molecular Weight: 155.172
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID80366550
• Wikidata: Q82151814
• Mol file: 120351-90-8.mol

Synonyms:120351-90-8;2-(2-FLUOROPHENOXY)ETHYLAMINE;2-(2-Fluorophenoxy)ethanamine;2-(2-Fluorophenoxy)-1-ethanamine;2-(2-Fluoro-phenoxy)-ethylamine;Ethanamine, 2-(2-fluorophenoxy)-;2-(2-fluorophenoxy)ethan-1-amine;2-(2-Fluorophenoxy)ethanamine, HCl;MFCD00235182;EC-000.1968;SCHEMBL3174750;DTXSID80366550;BBL002954;STK519360;AKOS000116932;AM91101;SB75885;AS-31711;BP-10542;SY008272;Ethanamine, 2-(2-fluorophenoxy)- (9CI);BB 0220201;CS-0128819;FT-0668681;EN300-34141;A892239

Chemical Property of 2-(2-Fluorophenoxy)ethylamine

Chemical Property:

• Vapor Pressure: 0.0362mmHg at 25°C
• Boiling Point: 241.3°Cat760mmHg
• Flash Point: 99.7°C
• PSA: 35.25000
• Density: g/cm³
• LogP: 1.86350
• Sensitive.: Air Sensitive
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 155.074642105
• Heavy Atom Count: 11
• Complexity: 110

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-Fluorophenoxy)ethylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)OCCN)F
• Uses: 2-(2-Fluorophenoxy)-1-ethanamine is a novel phenoxyalkylamine derivative useful as inhibitor of herpes viruses.

Technology Process of 2-(2-Fluorophenoxy)ethylamine

There total 3 articles about 2-(2-Fluorophenoxy)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-(2-(2-fluorophenoxy)ethyl)isoindoline-1,3-dione (350707-57-2) → 2-(2-fluorophenoxy)ethanamine (120351-90-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 1h; Reflux;

DOI:10.2478/s11532-013-0302-8

Reference yield: 67.0%

1-(2-bromoethoxy)-2-fluorobenzene (193220-21-2) → 2-(2-fluorophenoxy)ethanamine (120351-90-8)

Guidance literature:

1-(2-bromoethoxy)-2-fluorobenzene; With potassium phtalimide; In N,N-dimethyl-formamide; at 90 - 95 ℃; for 5h;

With hydrazine hydrate; In ethanol; for 1h; Heating;

With hydrogenchloride; at 90 - 100 ℃; for 1.5h;

DOI:10.1023/A:1009545706314

Reference yield:

2-fluorophenol (367-12-4) → 2-(2-fluorophenoxy)ethanamine (120351-90-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 51 percent / NaOH / H₂O / 7 h / Heating

2.1: potassium phthalimide / dimethylformamide / 5 h / 90 - 95 °C

2.2: hydrazine hydrate / ethanol / 1 h / Heating

2.3: 67 percent / aq. HCl / 1.5 h / 90 - 100 °C

With sodium hydroxide; potassium phtalimide; In water; N,N-dimethyl-formamide;

DOI:10.1023/A:1009545706314

upstream raw materials:

1-(2-bromoethoxy)-2-fluorobenzene

2-fluorophenol

2-(2-(2-fluorophenoxy)ethyl)isoindoline-1,3-dione

Downstream raw materials:

1-(6-Chloro-pyridazin-3-yloxy)-3-[2-(2-fluoro-phenoxy)-ethylamino]-propan-2-ol

C₂₅H₂₅FN₄O₂

(S)-3-(2-cyanophenoxy)-N-(2-(2-fluorophenoxy)ethyl)-2-hydroxypropan-1-aminium trifluoroacetate

2-{3-[2-(2-fluorophenoxy)-ethylamino]-1-propyl}-3(2H)-pyridazinone

Refernces

• 1、 Li, Linhu,Lv, Kai,Yang, Yupeng,Sun, Jingquan,Tao, Zeyu,Wang, Apeng,Wang, Bin,Wang, Hongjian,Geng, Yunhe,Liu, Mingliang,Guo, Huiyuan,Lu, Yu. "Identification of N-Benzyl 3,5-Dinitrobenzamides Derived from PBTZ169 as Antitubercular Agents". . p. 741 - 745. Retrieved 2018/07/05.
• 2、 Reznik,Akamsin,Galyametdinova. "Two-fragment α-adrenolytics 4. Synthesis of phosphorylated derivatives of 2-aryloxyethylamines and N-phenylpiperazine". . p. 125 - 129. Retrieved 2007/10/03.