3,6-Difluoropyrazine-2-carbonitrile

Base Information

• Chemical Name: 3,6-Difluoropyrazine-2-carbonitrile
• CAS No.: 356783-28-3
• Molecular Formula: C5HF2N3
• Molecular Weight: 141.08
• Hs Code.: 2933990090
• Mol file: 356783-28-3.mol

Synonyms:QC-769;2-Pyrazinecarbonitrile,3,6-difluoro;3,6-difluoro-2-pyrazinecarbonitrile;

Chemical Property of 3,6-Difluoropyrazine-2-carbonitrile

Chemical Property:

• Boiling Point: 206.5±35.0 °C(Predicted)
• PKA: -7.28±0.10(Predicted)
• PSA: 49.57000
• Density: 1.47±0.1 g/cm3(Predicted)
• LogP: 0.62648
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3,6-Difluoropyrazine-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,6-difluoropyrazine-2-carbonitrile is used in multi-step synthesis of Favipiravir from Aminopyrazine.

Technology Process of 3,6-Difluoropyrazine-2-carbonitrile

There total 19 articles about 3,6-Difluoropyrazine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,6-dichloropyrazine-2-carbonitrile (356783-16-9) → 3,6-difluoropyrazine-2-carbonitrile (356783-28-3)

Guidance literature:

With potassium fluoride; tetrabutylammomium bromide; In dimethyl sulfoxide; at 60 ℃; for 3h;

DOI:10.1039/d1ra06963b

Reference yield: 91.2%

6-chloro-3-bromo-2-cyanopyrazine → 3,6-difluoropyrazine-2-carbonitrile (356783-28-3)

Guidance literature:

With potassium fluoride; In N,N-dimethyl-formamide; at 80 - 85 ℃; for 20h;

Reference yield: 49.0%

6-bromo-3-chloropyrazine-2-carbonitrile (1257072-34-6) → 3,6-difluoropyrazine-2-carbonitrile (356783-28-3)

Guidance literature:

With potassium fluoride; tetrabutylammomium bromide; In dimethyl sulfoxide; toluene; at 70 - 100 ℃; for 4h;

upstream raw materials:

3,6-dichloropyrazine-2-carbonitrile

6-fluoro-3-(phenylsulfonyl)-2-pyrazinecarbonitrile

3-hydroxy-2-pyrazinecarboxamide

6-bromo-3-chloropyrazine-2-carbonitrile

Downstream raw materials:

3,6-difluoropyrazine-2-carboxamide

6-fluoro-3-oxo-3,4-dihydro-2-pyrazinecarbonitrile

6-fluoro-3-methoxy-2-pyrazinecarbonitrile

favipiravir