CAS No.356783-28-3,3,6-Difluoropyrazine-2-carbonitrile Suppliers

Products Categories

Pharmaceutical (65)
Organic Chemicals (6)
Others (2)
Materials (2)

Basic Information

Molecular Structure:
CAS No.:	356783-28-3
Name:	3,6-Difluoropyrazine-2-carbonitrile
Article Data:	17

Formula:	C5HF2N3
Molecular Weight:	141.08
Synonyms:	QC-769;2-Pyrazinecarbonitrile,3,6-difluoro;3,6-difluoro-2-pyrazinecarbonitrile;
EINECS:	202-303-5
Density:	1.47±0.1 g/cm3(Predicted)
Boiling Point:	206.5±35.0 °C(Predicted)
PSA:	49.57000
LogP:	0.62648

Synthetic route

: 356783-16-9
3,6-dichloropyrazine-2-carbonitrile

: 356783-28-3
3,6-difluoropyrazine-2-carbonitrile

Conditions

Conditions	Yield
With potassium fluoride; tetrabutylammomium bromide In dimethyl sulfoxide; toluene at 60℃; for 2.5h;	92.3%
With potassium fluoride In dimethyl sulfoxide at 60 - 90℃; Large scale;	85%
With tetrabutyl ammonium fluoride; tetrabutylammomium bromide at 60℃; for 3h; Reagent/catalyst; Temperature; Solvent; Sealed tube;	62.37%

: 6-chloro-3-bromo-2-cyanopyrazine

: 356783-28-3
3,6-difluoropyrazine-2-carbonitrile

Conditions

Conditions	Yield
With potassium fluoride In N,N-dimethyl-formamide at 80 - 85℃; for 20h;	91.2%

: 1257072-34-6
6-bromo-3-chloropyrazine-2-carbonitrile

: 356783-28-3
3,6-difluoropyrazine-2-carbonitrile

Conditions

Conditions	Yield
With potassium fluoride; tetrabutylammomium bromide In dimethyl sulfoxide; toluene at 70 - 100℃; for 4h;	49%
With potassium fluoride; tetrabutylammomium bromide In dimethyl sulfoxide; toluene at 70 - 100℃; for 4h;	49%
With potassium fluoride; tetrabutylammomium bromide In dimethyl sulfoxide at 70 - 100℃; for 4h;	49%
With potassium fluoride; tetrabutylammomium bromide In dimethyl sulfoxide; toluene at 70 - 100℃; for 3h;	49%

: 356783-59-0
6-fluoro-3-(phenylsulfonyl)-2-pyrazinecarbonitrile

: 356783-28-3
3,6-difluoropyrazine-2-carbonitrile

Conditions

Conditions	Yield
With potassium fluoride; tetrabutylammomium bromide In water; dimethyl sulfoxide; ethyl acetate

: 55321-99-8
2-hydroxypyrazine-3-carboxamide

: 356783-28-3
3,6-difluoropyrazine-2-carbonitrile

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: bromine / acetonitrile / 6 h / 0 - 40 °C 2.1: trichlorophosphate / chlorobenzene / 0.5 h / 60 °C 2.2: 2.67 h / 90 - 100 °C 3.1: potassium fluoride; tetrabutylammomium bromide / toluene; dimethyl sulfoxide / 2.5 h / 60 °C View Scheme
Multi-step reaction with 3 steps 1: tetrabutylammomium bromide; 2,6-dimethylpyridine / N,N-dimethyl-formamide / 17 h / 20 °C 2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / chlorobenzene / 17 h / 0 - 100 °C 3: tetrabutylammomium bromide; potassium fluoride / dimethyl sulfoxide; toluene / 4 h / 70 - 100 °C View Scheme
Multi-step reaction with 3 steps 1: 2,6-dimethylpyridine; tetrabutylammomium bromide / N,N-dimethyl-formamide / 17 h / 20 °C 2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / chlorobenzene / 17 h / 0 - 100 °C 3: potassium fluoride; tetrabutylammomium bromide / dimethyl sulfoxide; toluene / 4 h / 70 - 100 °C View Scheme

: 3-hydroxy-6-bromopyrazine-2-carboxamide

: 356783-28-3
3,6-difluoropyrazine-2-carbonitrile

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: trichlorophosphate / chlorobenzene / 0.5 h / 60 °C 1.2: 2.67 h / 90 - 100 °C 2.1: potassium fluoride; tetrabutylammomium bromide / toluene; dimethyl sulfoxide / 2.5 h / 60 °C View Scheme
Multi-step reaction with 2 steps 1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / chlorobenzene / 17 h / 0 - 100 °C 2: potassium fluoride; tetrabutylammomium bromide / dimethyl sulfoxide; toluene / 4 h / 70 - 100 °C View Scheme
Multi-step reaction with 2 steps 1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / water / 8 h / 60 - 100 °C 2: potassium fluoride; tetrabutylammomium bromide / toluene; dimethyl sulfoxide / 3 h / 55 °C View Scheme
Multi-step reaction with 2 steps 1.1: trichlorophosphate / 0.25 h / 70 °C 1.2: 6 h / 20 - 100 °C 1.3: 1 h 2.1: potassium fluoride dihydrate; tetrabutylammomium bromide / dimethyl sulfoxide / 3 h / 50 °C View Scheme
Multi-step reaction with 2 steps 1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / chlorobenzene / 17 h / 0 - 100 °C 2: potassium fluoride; tetrabutylammomium bromide / dimethyl sulfoxide; toluene / 3 h / 70 - 100 °C View Scheme

: 19847-12-2
2-pyrazine carbonitrile

: 356783-28-3
3,6-difluoropyrazine-2-carbonitrile

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: acetic acid; dihydrogen peroxide / 22 h / -5 - 95 °C 2.1: trichlorophosphate / 1.83 h / 50 - 70 °C 2.2: 6 h / 96 °C 3.1: potassium fluoride; tetrabutylammomium bromide / dimethyl sulfoxide / 3 h / 55 °C / Sealed tube View Scheme

: 18960-19-5
1,4-dioxopyrazinamide

: 356783-28-3
3,6-difluoropyrazine-2-carbonitrile

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: trichlorophosphate / 1.83 h / 50 - 70 °C 1.2: 6 h / 96 °C 2.1: potassium fluoride; tetrabutylammomium bromide / dimethyl sulfoxide / 3 h / 55 °C / Sealed tube View Scheme
Multi-step reaction with 2 steps 1.1: trichlorophosphate / chlorobenzene / 1.83 h / 50 - 70 °C 1.2: 8 h / 110 °C 2.1: tetrabutyl ammonium fluoride; tetrabutylammomium bromide / 3 h / 60 °C / Sealed tube View Scheme

: 5424-01-1
3-aminopyrazinoic acid

: 356783-28-3
3,6-difluoropyrazine-2-carbonitrile

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: sulfuric acid / 20 °C / Cooling with ice 2: N-Bromosuccinimide / acetonitrile / 20 °C 3: sulfuric acid; sodium nitrite / 2 h / -5 - 20 °C 4: ammonium hydroxide / 3 h / 20 °C 5: trichlorophosphate; N-ethyl-N,N-diisopropylamine / water / 8 h / 60 - 100 °C 6: potassium fluoride; tetrabutylammomium bromide / toluene; dimethyl sulfoxide / 3 h / 55 °C View Scheme
Multi-step reaction with 6 steps 1.1: sulfuric acid / 48 h / Cooling with ice 2.1: N-Bromosuccinimide / acetonitrile / 24 h / 20 °C / Inert atmosphere 3.1: sulfuric acid; sodium nitrite / 2 h / -5 - 25 °C 3.2: 1.5 h 4.1: ammonium hydroxide / 3 h / 20 °C 5.1: trichlorophosphate / 0.25 h / 70 °C 5.2: 6 h / 20 - 100 °C 5.3: 1 h 6.1: potassium fluoride dihydrate; tetrabutylammomium bromide / dimethyl sulfoxide / 3 h / 50 °C View Scheme

Yield

Multi-step reaction with 6 steps
1: sulfuric acid / 20 °C / Cooling with ice
2: N-Bromosuccinimide / acetonitrile / 20 °C
3: sulfuric acid; sodium nitrite / 2 h / -5 - 20 °C
4: ammonium hydroxide / 3 h / 20 °C
5: trichlorophosphate; N-ethyl-N,N-diisopropylamine / water / 8 h / 60 - 100 °C
6: potassium fluoride; tetrabutylammomium bromide / toluene; dimethyl sulfoxide / 3 h / 55 °C
View Scheme

Multi-step reaction with 6 steps
1.1: sulfuric acid / 48 h / Cooling with ice
2.1: N-Bromosuccinimide / acetonitrile / 24 h / 20 °C / Inert atmosphere
3.1: sulfuric acid; sodium nitrite / 2 h / -5 - 25 °C
3.2: 1.5 h
4.1: ammonium hydroxide / 3 h / 20 °C
5.1: trichlorophosphate / 0.25 h / 70 °C
5.2: 6 h / 20 - 100 °C
5.3: 1 h
6.1: potassium fluoride dihydrate; tetrabutylammomium bromide / dimethyl sulfoxide / 3 h / 50 °C
View Scheme

: 16298-03-6
Methyl 3-amino-2-pyrazinecarboxylate

: 356783-28-3
3,6-difluoropyrazine-2-carbonitrile

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: N-Bromosuccinimide / acetonitrile / 20 °C 2: sulfuric acid; sodium nitrite / 2 h / -5 - 20 °C 3: ammonium hydroxide / 3 h / 20 °C 4: trichlorophosphate; N-ethyl-N,N-diisopropylamine / water / 8 h / 60 - 100 °C 5: potassium fluoride; tetrabutylammomium bromide / toluene; dimethyl sulfoxide / 3 h / 55 °C View Scheme
Multi-step reaction with 5 steps 1.1: N-Bromosuccinimide / acetonitrile / 24 h / 20 °C / Inert atmosphere 2.1: sulfuric acid; sodium nitrite / 2 h / -5 - 25 °C 2.2: 1.5 h 3.1: ammonium hydroxide / 3 h / 20 °C 4.1: trichlorophosphate / 0.25 h / 70 °C 4.2: 6 h / 20 - 100 °C 4.3: 1 h 5.1: potassium fluoride dihydrate; tetrabutylammomium bromide / dimethyl sulfoxide / 3 h / 50 °C View Scheme

Country:
- China (Mainland)(75)
Business Type:
All

Lab/Research institutions

Trading Company

Manufacturers

Other
Certificate:
Manufacturer

Enterprise Authentication

ISO

GMP

FDA

HALAL