3-(tert-Butoxycarbonylamino)-2-methoxyisonicotinic acid

Base Information

• Chemical Name: 3-(tert-Butoxycarbonylamino)-2-methoxyisonicotinic acid
• CAS No.: 870997-82-3
• Molecular Formula: C12H16N2O5
• Molecular Weight: 268.269
• Hs Code.: 2933399090
• Mol file: 870997-82-3.mol

Synonyms:3-[(t-butoxycarbonyl)amino]-2-methoxyisonicotinic acid; 3-[(tert-butoxycarbonyl)amino]-2-methoxypyridine-4-carboxylic acid; 3-(tert-butoxycarbonylamino)-2-methoxyisonicotinic acid;

Chemical Property of 3-(tert-Butoxycarbonylamino)-2-methoxyisonicotinic acid

Chemical Property:

• Boiling Point: 412.0±45.0 °C(Predicted)
• PKA: 12.69±0.70(Predicted)
• PSA: 97.75000
• Density: 1.288±0.06 g/cm3(Predicted)
• LogP: 2.20840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-(tert-Butoxycarbonylamino)-2-methoxyisonicotinic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(tert-Butoxycarbonylamino)-2-methoxyisonicotinic acid

There total 1 articles about 3-(tert-Butoxycarbonylamino)-2-methoxyisonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-2-methoxypyridine (20265-38-7) + di-tert-butyl dicarbonate (24424-99-5) → 3-[(t-butoxycarbonyl)amino]-2-methoxyisonicotinic acid (870997-82-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hexamethyldisilazane / tetrahydrofuran

2: n-butyllithium; N,N,N,N,-tetramethylethylenediamine / hexane / -78 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sodium hexamethyldisilazane; In tetrahydrofuran; hexane;

DOI:10.1016/j.bmcl.2013.08.082

Reference yield: 88.0%

3-[(t-butoxycarbonyl)amino]-2-methoxyisonicotinic acid (870997-82-3) → 3-amino-2-methoxyisonicotinic acid (870997-81-2)

Guidance literature:

With trifluoroacetic acid; In methanol; chloroform; at 20 ℃; for 8h;

DOI:10.1016/j.bmcl.2008.10.034

Reference yield:

3-[(t-butoxycarbonyl)amino]-2-methoxyisonicotinic acid (870997-82-3) → 2-chloro-3-aminopyridine (6298-19-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2013.08.082

upstream raw materials:

3-amino-2-methoxypyridine

di-tert-butyl dicarbonate

Downstream raw materials:

3-amino-2-methoxyisonicotinic acid

2-chloro-3-aminopyridine