2-BOC-Aminomethyl-phenylboronic acid pinacol ester

Base Information

• Chemical Name: 2-BOC-Aminomethyl-phenylboronic acid pinacol ester
• CAS No.: 905300-76-7
• Molecular Formula: C18H28BNO4
• Molecular Weight: 333.236
• Hs Code.: 2934999090
• Mol file: 905300-76-7.mol

Synonyms:2-BOC-AMINOMETHYL-PHENYLBORONIC ACID PINACOL ESTER;2-(tert-Butoxycarbonylaminomethyl)phenylboronicacid, pinacol ester

Chemical Property of 2-BOC-Aminomethyl-phenylboronic acid pinacol ester

Chemical Property:

• PSA: 56.79000
• LogP: 3.40140
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Boc-Aminomethyl-phenylboronic acid pinacol ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BOC-Aminomethyl-phenylboronic acid pinacol ester

There total 3 articles about 2-BOC-Aminomethyl-phenylboronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

bis(pinacol)diborane (73183-34-3) + N-(tert-butoxycarbonyl)-2-bromobenzylamine (162356-90-3) → tert-butyl (2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)carbamate (905300-76-7)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 100 ℃; for 15h; Inert atmosphere;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)carbamate (905300-76-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

2-bromobenzylamine (3959-05-5) → tert-butyl (2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)carbamate (905300-76-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

di-tert-butyl dicarbonate

2-bromobenzylamine

bis(pinacol)diborane

N-(tert-butoxycarbonyl)-2-bromobenzylamine

Downstream raw materials:

C₂₁H₁₉N₅S

C₂₁H₂₅N₅S

C₁₉H₁₇N₅OS

TH₀₄₃₀₆-009

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