Pyrido[2,3-b]pyrazin-7-ylboronic acid pinacol ester

Base Information

• Chemical Name: Pyrido[2,3-b]pyrazin-7-ylboronic acid pinacol ester
• CAS No.: 1210047-44-1
• Molecular Formula: C13H16BN3O2
• Molecular Weight: 257.1
• Hs Code.: 2934999090
• Mol file: 1210047-44-1.mol

Synonyms:7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrido[2,3-b]pyrazine;

Chemical Property of Pyrido[2,3-b]pyrazin-7-ylboronic acid pinacol ester

Chemical Property:

• Melting Point: 167-172°C
• PSA: 57.13000
• LogP: 1.32400
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Pyrido[2,3-b]pyrazin-7-ylboronic acid pinacol ester 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

Useful:

Technology Process of Pyrido[2,3-b]pyrazin-7-ylboronic acid pinacol ester

There total 1 articles about Pyrido[2,3-b]pyrazin-7-ylboronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-bromo-pyrido[2,3-b]pyrazine (52333-42-3) + bis(pinacol)diborane (73183-34-3) → 7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyrido[2,3-b]pyrazine (1210047-44-1)

Guidance literature:

With potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tricyclohexylphosphine; In 1,4-dioxane; at 80 ℃; Inert atmosphere;

Reference yield: 57.0%

methyl 2-((4-bromo-3-methyl-1-(2-methylphenyl)-1H-pyrazol-5-yl)amino)-5-methoxylbenzoate (870188-37-7) + 7-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyrido[2,3-b]pyrazine (1210047-44-1) → methyl 5-methoxy-2-((3-methyl-1-(2-methylphenyl)-4-(pyrido[2,3-b]pyrazin-7-yl)-1H-pyrazol-5-yl)amino)benzoate (1210047-45-2)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 110 ℃; for 0.333333h; Inert atmosphere;

upstream raw materials:

7-bromo-pyrido[2,3-b]pyrazine

bis(pinacol)diborane

Downstream raw materials:

methyl 5-methoxy-2-((3-methyl-1-(2-methylphenyl)-4-(pyrido[2,3-b]pyrazin-7-yl)-1H-pyrazol-5-yl)amino)benzoate

Refernces