Benzo[C][1,2,5]thiadiazole-5-boronic acid pinacol ester, 97%

Base Information

• Chemical Name: Benzo[C][1,2,5]thiadiazole-5-boronic acid pinacol ester, 97%
• CAS No.: 1168135-03-2
• Molecular Formula: C12H17BN2O3S
• Molecular Weight: 262.14
• Hs Code.: 2934999090
• Mol file: 1168135-03-2.mol

Synonyms:Benzo[C][1,2,5]thiadiazole-5-boronic acid pinacol ester, 97%;2,1,3-Benzothiadiazole, 5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-;5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,1,3-benzothiadiazole, 2-(2,1,3-Benzothiadiazol-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property of Benzo[C][1,2,5]thiadiazole-5-boronic acid pinacol ester, 97%

Chemical Property:

• Melting Point: 81-86°C
• Boiling Point: 366.3±15.0 °C(Predicted)
• PKA: -0.02±0.36(Predicted)
• PSA: 72.48000
• Density: 1.22±0.1 g/cm3(Predicted)
• LogP: 1.99050
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)benzo[1,2,5]thiadiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

Useful:

• Uses: Benzo[c][1,2,5]thiadiazol-5-ylboronic acid pinacol ester can be used as a reactant: To synthesize 5-methylbenzo[c][1,2,5]thiadiazole by methylation reaction with methyl iodide using palladium catalyst. In the Miyaura borylation and Suzuki coupling reactions. To prepare benzothiadiazole derivatives as potent PFKFB3 kinase inhibitors.

Technology Process of Benzo[C][1,2,5]thiadiazole-5-boronic acid pinacol ester, 97%

There total 4 articles about Benzo[C][1,2,5]thiadiazole-5-boronic acid pinacol ester, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

5-bromobenzo[c][1,2,5]thiadiazole (1753-75-9) + 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (61676-62-8) → 5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzo[c][1,2,5]thiodiazole (1168135-03-2)

Guidance literature:

5-bromobenzo[c][1,2,5]thiadiazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere; Schlenk technique;

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1039/c6ra06616j

Reference yield:

5-bromobenzo[c][1,2,5]thiadiazole (1753-75-9) → 5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzo[c][1,2,5]thiodiazole (1168135-03-2)

Guidance literature:

With potassium acetate; In N,N-dimethyl-formamide;

Reference yield:

5-bromobenzo[c][1,2,5]thiadiazole (1753-75-9) + bis(pinacol)diborane (73183-34-3) → 5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzo[c][1,2,5]thiodiazole (1168135-03-2)

Guidance literature:

With C₅₄H₄₄NO₂PPdS; potassium acetate; In 2-methyltetrahydrofuran; at 90 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.9b02414

upstream raw materials:

5-bromobenzo[c][1,2,5]thiadiazole

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

4-Bromo-benzene-1,2-diamine

bis(pinacol)diborane

Downstream raw materials:

2-(4-benzo[c][1,2,5]thiadiazol-5-yl-3-chloro-5-cyclopropylmethoxyphenyl)-4-methylpentanoic acid cyclopropylmethyl ester

ethyl 2-(3-(benzo[c][1,2,5]thiadiazol-5-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoate

5-methylbenzo[c][1,2,5]thiadiazole

benzo[1,2,5]thiadiazol-5-ol

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1168135-03-2 Benzo[C][1,2,5]thiadiazole-5-boronic acid pinacol ester, 97%

Send

Send

Metric Ton KG G Pound L ML

Send

Send