2-(trifluoroMethyl)isonicotinoyl chloride

Base Information

• Chemical Name: 2-(trifluoroMethyl)isonicotinoyl chloride
• CAS No.: 1019201-53-6
• Molecular Formula: C18H24N2O6
• Molecular Weight: 364.39
• Mol file: 1019201-53-6.mol

Synonyms:1-[(Benzyloxy)carbonyl]-4-(tert-butoxycarbonyl)piperazine-2-carboxylic acid;Piperazine-1,2,4-tricarboxylic acid 1-benzyl ester 4-tert-butyl ester;

Chemical Property of 2-(trifluoroMethyl)isonicotinoyl chloride

Chemical Property:

• PSA: 29.96000
• LogP: 2.47940

Purity/Quality:

99%, ^*data from raw suppliers

2-(Trifluoromethyl)isonicotinoylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(trifluoroMethyl)isonicotinoyl chloride

There total 1 articles about 2-(trifluoroMethyl)isonicotinoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(trifluoromethyl)-4-pyridinecarboxylic acid (131747-41-6) → 2-(trifluoromethyl)isonicotinoyl chloride (1019201-53-6)

Guidance literature:

With thionyl chloride; for 2h; Reflux;

DOI:10.1021/acs.jmedchem.6b00943

Reference yield: 63.7%

2-(trifluoromethyl)isonicotinoyl chloride (1019201-53-6) + 2-(aminomethyl)-1,6-dimethyl-3-(phenylmethoxy)-4(1H)-pyridinone (401792-02-7) → N-((3-(benzyloxy)-1,6-dimethyl-4-oxo-1,4-dihydropyridin-2-yl)methyl)-2-(trifluoromethyl)isonicotinamide

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c00763

Reference yield:

3-ethynyl-4-methylaniline (134690-40-7) + 2-(trifluoromethyl)isonicotinoyl chloride (1019201-53-6) → N-(3-ethynyl-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethyl acetate; at 0 - 20 ℃; for 0.5h;

DOI:10.1021/acs.jmedchem.6b00943

upstream raw materials:

2-(trifluoromethyl)-4-pyridinecarboxylic acid

Downstream raw materials:

2-(trifluoromethyl)pyridine-4-carbonitrile

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