(R)-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-3-((3,5-dichloro-4-fluoro-[1,1-biphenyl]-4-yl)Methyl)-4-oxobutanal

Base Information

Chemical Name:(R)-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-3-((3,5-dichloro-4-fluoro-[1,1-biphenyl]-4-yl)Methyl)-4-oxobutanal
CAS No.:955406-65-2
Molecular Formula:C27H22Cl2FNO4
Molecular Weight:514.38
Hs Code.:
Mol file:955406-65-2.mol

Synonyms:Butanoic acid,3-[(tetrahydro-2H-pyran-2-yl)oxy]-,(3R);(R)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-4-oxo-butyraldehyde;(R)-3-tetrahydropyranyloxybutanoic acid;

Suppliers and Price of (R)-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-3-((3,5-dichloro-4-fluoro-[1,1-biphenyl]-4-yl)Methyl)-4-oxobutanal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 4 raw suppliers

Chemical Property of (R)-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-3-((3,5-dichloro-4-fluoro-[1,1-biphenyl]-4-yl)Methyl)-4-oxobutanal

Chemical Property:

PSA：63.68000
LogP:5.64530

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-3-((3,5-dichloro-4-fluoro-[1,1-biphenyl]-4-yl)Methyl)-4-oxobutanal

There total 8 articles about (R)-4-((R)-4-benzyl-2-oxooxazolidin-3-yl)-3-((3,5-dichloro-4-fluoro-[1,1-biphenyl]-4-yl)Methyl)-4-oxobutanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 955406-64-1
(R)-4-Benzyl-3-[(S)-2-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-pent-4-enoyl]-oxazolidin-2-one

: 955406-65-2
(R)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-4-oxo-butyraldehyde

Guidance literature:: With ozone; In methanol; dichloromethane; at -78 - -71 ℃; Cooling with acetone-dry ice;

Reference yield:

: 118-69-4
2,6-dichlorotoluene

: 955406-65-2
(R)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-4-oxo-butyraldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: [2,2]bipyridinyl / chloro(1,5-cyclooctadiene)iridium(I) dimer / n-heptane / 4 h / 100 °C

2.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; isopropyl alcohol / 8 h / 75 °C

3.1: N-Bromosuccinimide; dibenzoyl peroxide / chlorobenzene / 1 - 2 h / 85 - 120 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 - -25 °C / Cooling with acetone-dry ice

4.2: -78 - 20 °C / Cooling with acetone-dry ice

5.1: ozone / methanol; dichloromethane / -78 - -71 °C / Cooling with acetone-dry ice

With [2,2]bipyridinyl; N-Bromosuccinimide; potassium carbonate; ozone; lithium hexamethyldisilazane; dibenzoyl peroxide; palladium diacetate; chloro(1,5-cyclooctadiene)iridium(I) dimer; triphenylphosphine; In tetrahydrofuran; methanol; n-heptane; dichloromethane; water; chlorobenzene; isopropyl alcohol;

Reference yield:

: 942069-73-0
2-(3,5-dichloro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 955406-65-2
(R)-4-((R)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-(3,5-dichloro-4'-fluoro-biphenyl-4-ylmethyl)-4-oxo-butyraldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; isopropyl alcohol / 8 h / 75 °C

2.1: N-Bromosuccinimide; dibenzoyl peroxide / chlorobenzene / 1 - 2 h / 85 - 120 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.17 h / -78 - -25 °C / Cooling with acetone-dry ice

3.2: -78 - 20 °C / Cooling with acetone-dry ice

4.1: ozone / methanol; dichloromethane / -78 - -71 °C / Cooling with acetone-dry ice

With N-Bromosuccinimide; potassium carbonate; ozone; lithium hexamethyldisilazane; dibenzoyl peroxide; palladium diacetate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; chlorobenzene; isopropyl alcohol;