118-69-4

Basic information

• Product Name: 2,6-Dichlorotoluene
• Synonyms: 2,6-two chlorotoluene;2.6-Dichloroto;1,3-dichloro-2-methyl-benzen;2,6-dichloro-toluen;Benzene,1,3-dichloro-2-methyl-;Toluene, 2,6-dichloro-;DICHLOROTOLUENE MIXTURE;1,3-DICHLORO-2-METHYLBENZENE
• CAS NO: 118-69-4
• Molecular Formula: C₇H₆Cl₂
• Molecular Weight: 161.03
• EINECS: 204-269-7
• Product Categories: Chemical Synthesis;Halogenated Hydrocarbons;Organic Building Blocks;Aromatic Hydrocarbons (substituted) & Derivatives;Halogen toluene;Chlorine Compounds;Alpha Sort;Analytical Standards;AromaticsChemical Class;Chemical Class;ChloroVolatiles/ Semivolatiles;D;DAlphabetic;DIA - DIC;Halogenated;Aryl;C7;Halogenated Hydrocarbons;Building Blocks
• Mol File: 118-69-4.mol
• Article Data: 16

Chemical Properties

• Melting Point: 2 °C
• Boiling Point: 196-203 °C(lit.)
• Flash Point: 82 °C
• Appearance: Clear colorless to slightly yellow/Liquid
• Density: 1.254 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.561mmHg at 25°C
• Refractive Index: n20/D 1.55(lit.)
• Storage Temp.: Store below +30°C.
• Solubility: 26mg/l insoluble
• Water Solubility: 24 mg/L (20 ºC)
• BRN: 1907194
• CAS DataBase Reference: 2,6-Dichlorotoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichlorotoluene(118-69-4)
• EPA Substance Registry System: 2,6-Dichlorotoluene(118-69-4)

Safety Data

• Hazard Codes: T,Xi,Xn
• Statements: 22-23-37/38-40-41-36/37/38
• Safety Statements: 26-36/37/39-45-24/25-37/39
• RIDADR: UN 2810
• WGK Germany: 2
• TSCA: Yes
• HazardClass: 9
• PackingGroup: III
• Hazardous Substances Data: 118-69-4(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to slightly yellowish liquid

Uses

2,6-Dichlorotoluene is an important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.

Purification Methods

Fractionally distil it and collect the middle fraction. [Beilstein 5 IV 815.]

InChI:InChI=1/C7H6Cl2/c1-5-6(8)3-2-4-7(5)9/h2-4H,1H3

Synthetic route

3,5-dichloro-4-methylbenzenesulphonic acid (2225-18-5) → 2,6-dichlorotoluene (118-69-4)

Conditions	Yield
With copper(I) oxide; sulfuric acid In quinoline at 220℃; for 3h; Activation energy; Temperature;	93%

3-chloro-2-methylbenzenamine (87-60-5) → 2,6-dichlorotoluene (118-69-4)

Conditions	Yield
Stage #1: 3-chloro-2-methylbenzenamine With potassium nitrite; potassium chloride In water at 8 - 90℃; for 0.666667h; Stage #2: With nickel nitrate; potassium chloride In water at 60℃; for 2.83333h; Concentration; Temperature; Reagent/catalyst;	89%

1-methyl-pyrrolidin-2-one (872-50-4) + potassium methanolate (865-33-8) + metsulfovax (21452-18-6) → 2,6-dichlorotoluene (118-69-4)

Conditions	Yield
With dimethyl sulfate	82%
With dimethyl sulfate	82%

2-methylchlorobenzene (95-49-8) → 2,5-dichlorotoluene (19398-61-9) + 2,6-dichlorotoluene (118-69-4) + 2,4-dichlorotoluene (95-73-8) + 2,3-dichlorotoluene (32768-54-0)

Conditions	Yield
bei der Chlorierung;
With sulfuric acid; 1-butyl-3-methylimidazolium chloroaluminate; chlorine at 30℃; for 12h; Reagent/catalyst; Temperature;
With sulfuric acid; chlorine at 35℃; for 12h; Temperature; Molecular sieve;

2-methylchlorobenzene (95-49-8) → 2,6-dichlorotoluene (118-69-4)

Conditions	Yield
With iron durch Chlorierung;

2,6-dichlorobenzaldehyde hydrazone (59714-30-6) → 2,6-dichlorotoluene (118-69-4)

Conditions	Yield
With potassium hydroxide at 150℃;

3-nitro-o-tolylamine (603-83-8) → 2,6-dichlorotoluene (118-69-4)

Conditions	Yield
Austausch der Aminogruppe gegen Chlor, Reduktion und Ersatz der neuentstandenen Aminogruppe durch Chlor;
Austausch der Aminogruppe gegen Chlor, Reduktion und Ersatz der neuentstandenen Aminogruppe durch Chlor;

p-toluenesulfonyl chloride (98-59-9) → 2,6-dichlorotoluene (118-69-4) + 1,2,4-trichloro-3-methylbenzene (2077-46-5)

Conditions	Yield
at 70 - 80℃; durch Chlorierung; in Gegenwart von Chloruebertraegern; Verseifung des entstandenen Gemisches von Sulfochloriden und Abspaltung der Sulfogruppe aus den Sulfonsaeuren;
With chlorine at 70 - 80℃; durch Chlorieren; Verseifung des entstandenen Gemisches von Sulfochloriden und Abspaltung der Sulfogruppe aus den Sulfonsaeuren;

toluene (108-88-3) → 2,6-dichlorotoluene (118-69-4)

Conditions	Yield
With molybdenum(V) chloride durch Chlorierung;

1-(2',6'-Dichlorobenzyl)-1,4-dihydronicotinamide (13502-54-0) → 2,6-dichlorotoluene (118-69-4) + nicotinamide (98-92-0) + 1,4-Bis-(2,6-dichloro-benzyl)-1,4-dihydro-pyridine-3-carboxylic acid amide (103872-42-0) + trans-5-(2,6-dichlorobenzyl)-6-methoxy-1,4,5,6-tetrahydronicotinamide (103872-43-1, 103872-44-2)

Conditions	Yield
In methanol for 7h; Irradiation; Further byproducts given;	A 10 % Turnov. B 24 % Turnov. C 13 % Turnov. D 29 % Turnov.

1,3-Dichlorobenzene (541-73-1) + methyl iodide (74-88-4) → 2,6-dichlorotoluene (118-69-4)

Conditions	Yield
With n-butyllithium 1.) hexane,THF, -65 to -70 deg C, 45 min, 2.) THF, -70 deg C, 45 min; Yield given. Multistep reaction;
Stage #1: 1,3-Dichlorobenzene With sodium; diisopropylamine; isoprene In tetrahydrofuran at -20℃; for 0.000138889h; Flow reactor; Stage #2: methyl iodide In tetrahydrofuran Flow reactor;	33 mg

2.6-dichloro-toluene-sulfonic acid-(4) → 2,6-dichlorotoluene (118-69-4)

Conditions	Yield
With sulfuric acid at 250℃; bei der Destillation mit ueberhitztem Wasserdampf;

sulfuric acid (7664-93-9) + 3,5-dichloro-4-methylbenzenesulphonic acid (2225-18-5) → 2,6-dichlorotoluene (118-69-4)

Conditions	Yield
at 250℃; bei der Destillation mit ueberhitztem Wasserdampf;

2-(2,6-dichlorophenyl)ethan-1-ol (30595-79-0) → 2,6-dichlorotoluene (118-69-4) + 2,6-dichlorostyrene (28469-92-3) + 4-chloro-2,3-dihydro-1-benzofuran (289058-20-4)

Conditions	Yield
Stage #1: 2-(2,6-dichlorophenyl)ethan-1-ol With sodium hydride In pyridine at 40℃; for 0.25h; Metallation; Stage #2: copper(l) chloride In pyridine for 2h; Cyclization; Ullman reaction; Heating;

2,4,6-trichlorotoluene (23749-65-7) → para-chlorotoluene (106-43-4) + 2-methylchlorobenzene (95-49-8) + 2,6-dichlorotoluene (118-69-4) + 2,4-dichlorotoluene (95-73-8)

Conditions	Yield
With tetraethylammonium bromide In methanol Electrolysis; Title compound not separated from byproducts;

2,6-dichlorobenzaldehyde (2,6-dichlorobenzylidene)hydrazone (32188-71-9) → 2,6-dichlorotoluene (118-69-4)

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrazine hydrate 2: KOH / 150 °C View Scheme

2,6-dichlorobenzaldehyde (83-38-5) → 2,6-dichlorotoluene (118-69-4)

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrazine hydrate 2: KOH / 150 °C View Scheme

3,5-dichloro-4-methylbenzoic acid (39652-34-1) → 2,6-dichlorotoluene (118-69-4)

Conditions	Yield
With copper(I) oxide In quinoline at 220℃; Autoclave;

toluene-4-sulfonic acid (104-15-4) → 2,6-dichlorotoluene (118-69-4)

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride; dihydrogen peroxide / water / 4 h / 60 °C 2: sulfuric acid; copper(I) oxide / quinoline / 3 h / 220 °C View Scheme

p-Toluic acid (99-94-5) → 2,6-dichlorotoluene (118-69-4)

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride; dihydrogen peroxide / water / 4 h / 60 °C 2: copper(I) oxide / quinoline / 220 °C / Autoclave View Scheme

2,3-dichlorotoluene (32768-54-0) → 2,6-dichlorotoluene (118-69-4)

Conditions	Yield
Stage #1: 2,3-dichlorotoluene With chlorine Stage #2: With hydrogen at 150℃; under 375.038 Torr; for 1h; Temperature; Pressure;

2,6-dichlorotoluene (118-69-4) → 2,4-dichloro-3-methylbromobenzene (127049-87-0)

Conditions	Yield
With bromine; iodine; iron In tetrachloromethane at 20℃; for 3.33333h;	100%
With bromine; iodine; iron In tetrachloromethane at 20℃; for 48h;

2,6-dichlorotoluene (118-69-4) + iron (7439-89-6) → 2,4-dichloro-3-methylbromobenzene (127049-87-0)

Conditions	Yield
With bromine; iodine In tetrachloromethane; (2S)-N-methyl-1-phenylpropan-2-amine hydrate	99.5%

2,6-dichlorotoluene (118-69-4) → 2,6-Dichlorobenzyl bromide (20443-98-5)

Conditions	Yield
With sodium bromate; hydrogen bromide In water at 60℃; for 3.83333h; Temperature; Flow reactor; Irradiation; Green chemistry; Large scale;	97%
With N-Bromosuccinimide In acetonitrile at 10 - 30℃; for 2.16667h; Solvent; Irradiation;	93%
With bromine

methanol (67-56-1) + 2,6-dichlorotoluene (118-69-4) + sodium methylate (124-41-4) → 1-chloro-3-methoxy-2-methylbenzene (3260-88-6)

Conditions	Yield
Stage #1: methanol; 2,6-dichlorotoluene; sodium methylate In dimethyl sulfoxide at 160℃; for 8h; Stage #2: With polyethylene glycol 600 In dimethyl sulfoxide at 80℃; for 2h; Temperature; Reagent/catalyst; Concentration;	95.6%

2,6-dichlorotoluene (118-69-4) → 2,6-dichloro-3-nitrotoluene (29682-46-0)

Conditions	Yield
With sulfuric acid; nitric acid In dichloromethane at 20℃; for 2h;	95%
With nitric acid In 1,2-dichloro-ethane at 30 - 45℃; for 2h;	90%
bei der Nitrierung;
With sulfuric acid; nitric acid
With nitric acid

2,6-dichlorotoluene (118-69-4) → 2,6-dichlorobenzoic acid (50-30-6)

Conditions	Yield
	95%
With potassium permanganate; water
With nitric acid at 140℃; im Druckrohr;

2,6-dichlorotoluene (118-69-4) + acetyl chloride (75-36-5) → 1-(2,4-dichloro-3-methylphenyl)ethanone (157652-32-9)

Conditions	Yield
With aluminum (III) chloride at 40℃; for 2h;	95%
With aluminum (III) chloride at 20 - 40℃;	85%
With aluminum (III) chloride In dichloromethane at 20℃; for 16h; Reflux;	75%

2,6-dichlorotoluene (118-69-4) + acetyl chloride (75-36-5) → 2,4-dichloro-3-methylacetophenone

Conditions	Yield
With aluminum (III) chloride at 20 - 40℃; for 2h;	95%

2,6-dichlorotoluene (118-69-4) + o-chlorobenzoyl chloride (609-65-4) → 2-chloro-6-(2-chlorobenzoyl)toluene

Conditions	Yield
Stage #1: 2,6-dichlorotoluene With iodine; magnesium In tetrahydrofuran for 4h; Inert atmosphere; Stage #2: o-chlorobenzoyl chloride In tetrahydrofuran; toluene for 24h; Cooling with ice; Reflux;	93.8%

2,6-dichlorotoluene (118-69-4) → 2,6-dichloro-3,5-dinitrotoluene (51676-76-7)

Conditions	Yield
With sulfuric acid; sulfur trioxide; nitric acid; dinitrogen tetraoxide at 0 - 100℃; Product distribution / selectivity; Inert atmosphere;	93.5%
With oleum; sulfuric acid; nitric acid at 0 - 100℃; Product distribution / selectivity; Inert atmosphere;	93.5%
With sulfuric acid; sulfur trioxide; nitric acid at 0 - 110℃;	86%

methylthiol (74-93-1) + 2,6-dichlorotoluene (118-69-4) → 3-chloro-2-methylphenyl methyl sulfide (82961-52-2)

Conditions	Yield
Stage #1: methylthiol With potassium hydroxide In toluene at 5℃; for 0.5h; Inert atmosphere; Stage #2: 2,6-dichlorotoluene With 1,4-diaza-bicyclo[2.2.2]octane In toluene at 52℃; for 5h; Reagent/catalyst; Temperature;	93.4%

2,6-dichlorotoluene (118-69-4) → 1,3-Dichloro-2-chloromethyl-benzene (2014-83-7)

Conditions	Yield
With copper(II) sulfide In hexane at 80 - 120℃; for 5h; Inert atmosphere;	90.3%
at 195 - 230℃; Irradiation.Einleiten von Chlor; UV-Licht;
With sulfuryl dichloride; dibenzoyl peroxide
With chlorine at 80℃; Temperature; UV-irradiation; Industrial scale;	1347.04 g

2,6-dichlorotoluene (118-69-4) → 1,2-bis-(2,6-dichlorophenyl)ethane (62120-70-1)

Conditions	Yield
With di-tert-butyl peroxide; sodium acetate at 120℃; for 10h; Schlenk technique; Green chemistry;	90%
With diacetyl peroxide
With Peroxydikohlensaeure-diethylester

2,6-dichlorotoluene (118-69-4) + benzoic acid (65-85-0) → 2,6-dichlorobenzyl benzoate (694525-13-8)

Conditions	Yield
With di-tert-butyl peroxide; C11H23N2(1+)*Br4Fe(1-) at 110℃; for 24h;	90%

2,6-dichlorotoluene (118-69-4) → 2,6-dichloro-benzonitrile (1194-65-6)

Conditions	Yield
With ethyl bromide; ammonia; oxygen; VPCoO/γ-Al2O3 at 350 - 400℃; for 0.00133333 - 0.00152778h;	89.5%
With ethyl bromide; ammonia; oxygen; VPCrO/TiO2 In water at 350 - 400℃; for 0.00133333 - 0.00152778h;	87.6%
With ammonia; oxygen; VPCoO/γ-Al2O3 In water at 350 - 400℃; for 0.00133333 - 0.00152778h;	86.8%

2,6-dichlorotoluene (118-69-4) → 1,2,4-trichloro-3-methylbenzene (2077-46-5)

Conditions	Yield
With antimony(III) chloride; chlorine at 25 - 30℃; under 760.051 Torr; for 6h; Time; Temperature; Reagent/catalyst;	86.3%
With aluminium; mercury durch Chlorierung;

2,6-dichlorotoluene (118-69-4) + sodium thiomethoxide (5188-07-8) → 3-chloro-2-methylphenyl methyl sulfide (82961-52-2) + 2-Methyl-3-methylthiobenzenethiol (82961-54-4)

Conditions	Yield
In N,N,N,N,N,N-hexamethylphosphoric triamide at 100℃; for 0.5h;	A 86% B 7%

2,6-dichlorotoluene (118-69-4) → 3-chloro-o-cresol (3260-87-5)

Conditions	Yield
With potassium hydroxide In methanol; water at 200℃; for 20h;	86%
With sodium methylate; sodium isopropanethiolate 1.) HMPA, 120 degC, 2h; 2.) 120 degC, 1h; Yield given. Multistep reaction;
Multi-step reaction with 2 steps 1: Pd(OAc)2; P(t-Bu)3 / xylene / 2 h / 120 °C 2: conc. HCl / 14 h View Scheme

2,6-dichlorotoluene (118-69-4) → 2,4-Dichloro-3-methylbenzenesulfonyl chloride (69145-58-0)

Conditions	Yield
With chlorosulfonic acid at 40℃; for 2h;	85%
With chlorosulfonic acid at 20 - 40℃; for 4h;	85%
With chlorosulphuric acid; sulfuric acid at 20 - 40℃; Chlorosulfonation;	83%
With chlorosulphuric acid
With chlorosulphuric acid

2,6-dichlorotoluene (118-69-4) → 2,6-dichlorobenzaldehyde (83-38-5)

Conditions	Yield
With nickel-doped graphene carbon nitride nanoparticles; air In ethanol at 25℃; for 8h; Irradiation; Green chemistry;	85%
With sodium persulfate; dipotassium peroxodisulfate; iron(II) acetylacetonate; tris(dibenzoylmethano)iron(III); Triethoxysilane In water; acetone at 80℃; for 17h;	60%
With sodium molybdenate; dihydrogen peroxide; cobalt(II) acetate; acetic acid; sodium bromide at 65℃; for 0.0555556h; Concentration; Temperature;	31.7%
With manganese(IV) oxide; sulfuric acid
With 2-chloro-benzaldehyde; chlorine; zinc(II) chloride; dibenzoyl peroxide at 110 - 140℃; for 21.3h; Reagent/catalyst;	187 g

2,6-dichlorotoluene (118-69-4) + 2-chlorobenzalacetone (91574-67-3, 91574-68-4, 20766-37-4) → C17H13Cl3O

Conditions	Yield
With di-tert-butyl peroxide; [copper(II)(trifluoroacetylacetonate)2]; salicylic acid at 120℃; for 24h; Inert atmosphere; regioselective reaction;	85%

2,6-dichlorotoluene (118-69-4) → 4,4'-sulfonylbis(1,3-dichloro-2-methylbenzene)

Conditions	Yield
With dipotassium peroxodisulfate; trifluorormethanesulfonic acid; tetra(n-butyl)ammonium hydrogensulfate; trifluoroacetic anhydride In 1,2-dichloro-ethane at 90℃; for 7h; Sealed tube;	81%
With cadmium(II) sulfate crystallohydrate; phosphorus pentoxide at 20℃; for 5h; Milling; Sealed tube; Green chemistry;	57%

2,6-dichlorotoluene (118-69-4) + Methanesulfonic anhydride (7143-01-3) → 2,6-dichloro-3-(methylsulfonyl)toluene (496805-63-1)

Conditions	Yield
With trifluorormethanesulfonic acid at 120℃; for 5h;	79%

2,6-dichlorotoluene (118-69-4) + copper(I) cyanide (544-92-3) → 2,6-dicyanotoluene (2317-22-8)

Conditions	Yield
With 1-methyl-pyrrolidin-2-one for 18h; Heating;	78%
With pyridine; copper(II) sulfate; benzonitrile

1-bromo-4-methoxy-benzene (104-92-7) + 2,6-dichlorotoluene (118-69-4) → 4,4''-dimethoxy-2'-methyl-1,1':3',1''-terphenyl (1359827-25-0)

Conditions	Yield
Stage #1: 1-bromo-4-methoxy-benzene With iodine; magnesium In diethyl ether for 1.5h; Reflux; Stage #2: 2,6-dichlorotoluene With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride In diethyl ether for 21h; Grignard reaction; Reflux; Stage #3: With hydrogenchloride In diethyl ether; water at 0℃; Grignard reaction;	78%

2,6-dichlorotoluene (118-69-4) + methyl iodide (74-88-4) + sodium thiomethoxide (5188-07-8) → 3-chloro-2-methylphenyl methyl sulfide (82961-52-2)

Conditions	Yield
In N,N,N,N,N,N-hexamethylphosphoric triamide; water	77%

Upstream product

• 95-49-8 2-methylchlorobenzene 
• 603-83-8 3-nitro-o-tolylamine 
• 83-38-5 2,6-dichlorobenzaldehyde 
• 872-50-4 1-methyl-pyrrolidin-2-one 
• 865-33-8 potassium methanolate 
• 21452-18-6 metsulfovax 
• 83-42-1 6-chloro-2-nitrotoluene 
• 87-60-5 3-chloro-2-methylbenzenamine 
• 99-94-5 p-Toluic acid 
• 104-15-4 toluene-4-sulfonic acid 
• 39652-34-1 3,5-dichloro-4-methylbenzoic acid 
• 2225-18-5 3,5-dichloro-4-methylbenzenesulphonic acid 
• 32188-71-9 2,6-dichlorobenzaldehyde (2,6-dichlorobenzylidene)hydrazone 
• 23749-65-7 2,4,6-trichlorotoluene 

Downstream Products

• 62120-70-1 1,2-bis-(2,6-dichlorophenyl)ethane 
• 98421-59-1 9,10-bis(3-chloro-2-methylphenyl)-9,10-dihydroxy-9,10-dihydrophenanthrene 
• 75896-78-5 3,3''-dichloro-2,2''-dimethyl-o-terphenyl 
• 75896-82-1 3,3'''-dichloro-2,2'''-dimethyl-o-quaterphenyl 
• 186977-62-8 [8-(3-Chloro-2-methyl-benzoyl)-naphthalen-1-yl]-(3-chloro-2-methyl-phenyl)-methanone 
• 186977-65-1 2,2-Bis-(3-chloro-2-methyl-phenyl)-2H-acenaphthylen-1-one 
• 4792-27-2 1,3-dihydro-1-oxo-4-isobenzofurancarboxylic acid 
• 91344-99-9 methyl 1,3-dihydro-1-oxo-4-isobenzofuranacetate 
• 3537-62-0 2-methyl-1,3-benzenedicarbonyl dichloride 
• 15120-47-5 2-methyl-1,3-benzenedicarbocylic acid 
• 16281-93-9 dimethyl 2-(bromomethyl)-1,3-benzenedicarboxylate 
• 87-60-5 3-chloro-2-methylbenzenamine 
• 82961-52-2 3-chloro-2-methylphenyl methyl sulfide 
• 3260-88-6 1-chloro-3-methoxy-2-methylbenzene 

Related news

Determination of isotope shifts in 2,4-, 3,4- and 2,6-Dichlorotoluene (cas 118-69-4) isomers in a supersonic beam09/01/2019

By using resonance-enhanced two-photon ionization in a supersonic beam, photoionization spectra of the m/z 160, 162 and 164 species of the 2,4-, 3,4- and 2,6-dichlorotoluene isomers at 0.8 K rotational temperature have been obtained in the 2800 Å spectral region. The ions have been analyzed acco...detailed

The kinetics of vapour-phase ammoxidation of 2,6-Dichlorotoluene (cas 118-69-4) over VPO catalyst08/29/2019

The kinetics of the vapour-phase ammoxidation of 2,6-dichlorotoluene (DCT) to 2,6-dichlorobenzonitrile (DCBN) over a vanadium phosphorus oxide (VPO) catalyst was investigated. In this paper, the main focus is on developing a mathematical model to describe the reaction kinetics of ammoxidation of...detailed

Synthesis of 2,6-dichlorobenzonitrile from 2,6-Dichlorotoluene (cas 118-69-4) by gas phase ammoxidation over VPO catalysts08/28/2019

Ammoxidation of 2,6-dichlorotoluene to 2,6-dichlorobenzonitrile is indeed an industrially important reaction for producing various commercially useful chemicals. In this contribution, differences in the catalytic performance of bulk, supported and promoted VPO samples are described. The choice o...detailed

Relevant articles and documents

Oxidative chlorination, desulphonation, or decarboxylation to synthesize pharmaceutical intermediates: 2,6-Dichlorotoluene, 2,6-dichloroaniline, and 2,6-dichlorophenol

An alternative manufacturing process scheme was developed for 2,6-dichlorotoluene, 2,6-dichloroaniline, and 2,6-dichlorophenol, involving oxidative chlorination after protection of the starting material in the para position followed by deprotection involving desulphonation or decarboxylation. Oxidative chlorination of 4-methylbenzenesulphonic acid, 4-methylbenzoic acid, 4-aminobenzoic acid, and 4-hydroxybenzoic acid by using HCl-H2O2, and their subsequent desulphonation or decarboxylation, gave a 60-75% yield of the desired product.

A process for preparing 2, 6 - dichloro toluene method (by machine translation)

The invention discloses a method for preparing 2, 6 - dichloro toluene, in this method, 2, 3 - dichloro toluene react with chlorine to obtain 2, 3 - benzene ring chlorinated product of abnormal growth; the hydrogen gas as a reducing agent, supported palladium catalyst catalytic reduction of 2, 3 - benzene ring of abnormal growth of chlorinated product so as to obtain 2, 6 - dichloro toluene, the reaction by-product is repeated chlorinated, catalytic reduction reaction, so that the 2, 3 - dichloro toluene is transformed 2, 6 - dichloro toluene yields up to 30% or more; 2, 6 - dichloro toluene as an important chemical industry intermediate, to generate new economic value. (by machine translation)

H β molecular sieve catalytic O-chlorotoluene preparation 2, 6 - dichloro toluene method (by machine translation)

The invention relates to 2, 6 - dichloro toluene preparation technology field, in particular to a molecular sieve catalyst H β of O-toluene selective chlorination of preparation 2, 6 - dichloro toluene. The invention relates to a low cost of O-toluene as the raw materials, chlorine is the chlorinating agent, H β molecular sieve as the catalyst, adopt the one-step chlorination process, catalytic O-toluene selective chlorination of preparation 2, 6 - dichloro toluene, the process is easy to operate, simple steps, low production cost, easy industrialization. (by machine translation)