2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid

Base Information

• Chemical Name: 2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid
• CAS No.: 1219143-85-7
• Molecular Formula: C25H21N3O4
• Molecular Weight: 427.46
• Mol file: 1219143-85-7.mol

Synonyms:2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid;alpha-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-1H-pyrrolo[2,3-b]pyridine-3-propanoic acid;(S)-N-FMoc-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid

Chemical Property of 2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid

Chemical Property:

• PSA: 104.31000
• Density: 1.382
• LogP: 4.48820
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic Acid is used as a reactant in the synthesis of template-fixed β-hairpin peptidomimetics as CCR10 antagonists.

Technology Process of 2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid

There total 1 articles about 2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + (S)-7-aza tryptophan → Fmoc-7-aza-L-tryptophan (1219143-85-7,737007-45-3)

Guidance literature:

With sodium carbonate; In water; acetone; at 10 - 20 ℃; for 2h;

DOI:10.1002/ejoc.202100485

Reference yield:

(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-(3-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ylsulfonyl)guanidino)hexanoic acid (1159680-21-3) + N-(tert-butoxycarbonyl)-4-aminobutanoic acid (57294-38-9) + Fmoc-7-aza-L-tryptophan (1219143-85-7,737007-45-3) + (S)-3-biphenyl-4-yl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionic acid (199110-64-0,205526-38-1) → (S)-2-((S)-3-([1,1'-biphenyl]-4-yl)-2-((S)-2-(4-aminobutanamido)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanamido)propanamido)-6-guanidinohexanamide

Guidance literature:

(S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-6-(3-(2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-ylsulfonyl)guanidino)hexanoic acid; With N-ethyl-N,N-diisopropylamine; ethyl cyanoglyoxylate-2-oxime; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

With 4-methylpiperidin; In N,N-dimethyl-formamide; at 20 ℃;

N-(tert-butoxycarbonyl)-4-aminobutanoic acid; Fmoc-7-aza-L-tryptophan; (S)-3-biphenyl-4-yl-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionic acid; Further stages;

DOI:10.1021/acs.jmedchem.1c00608

upstream raw materials:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

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