1159680-21-3

Basic information

• Product Name: L-Lysine, N6-[[[(2,3-dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-
• Synonyms: L-Lysine, N6-[[[(2,3-dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-;Fmoc-HoArg(Pbf);Fmoc-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-homoarginine≥ 98.5% (HPLC);(9H-Fluoren-9-yl)MethOxy]Carbonyl HoArg(Pbf)-OH
• CAS NO: 1159680-21-3
• Molecular Formula: C₃₅H₄₂N₄O₇S
• Molecular Weight: 662.81
• Mol File: 1159680-21-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.87±0.21(Predicted)
• CAS DataBase Reference: L-Lysine, N6-[[[(2,3-dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Lysine, N6-[[[(2,3-dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-(1159680-21-3)
• EPA Substance Registry System: L-Lysine, N6-[[[(2,3-dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-(1159680-21-3)

Safety Data

• Hazardous Substances Data: 1159680-21-3(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white crystalline powder

Uses

Fmoc-L-HomoArg(Pbf)-OH

Upstream product

• 139262-23-0 9-fluorenylmethoxycarbonyl-L-alanine hydrochloride 
• 71989-26-9 Fmoc-Lys(tert-butoxycarbonyl) 
• 154445-78-0 2,2,4,6,7-pentamethyl-2,3-dihydrobenzofuran-5-sulfonyl chloride 

Relevant articles and documents

Preparation method of eptifibatide key raw material L-higher arginine

The invention discloses a preparation method of an eptifibatide key raw material L-higher arginine, and belongs to the field of synthesis of medical intermediates. The preparation method comprises thefollowing steps: reacting 1,3-bis(tert-butyloxycarbonyl)guanidine with p-toluenesulfonyl chloride to obtain 1,3-bis-Boc-2-(p-toluenesulfonyl)guanidine, then reacting the 1,3-bis-Boc-2-(p-toluenesulfonyl)guanidine with N-fluorenylmethoxycarbonyl-N'-tert-butyloxycarbonyl-L-lysine Fmoc-hArg(Boc2)-OH, removing Boc protection, and feeding Pbf-Cl to obtain N-(9-fluorenylmethoxycarbonyl)-2,2,4,6,7-pentamethyl-2H-benzofuran-5-sulfonyl-L-arginine. According to the invention, a p-toluenesulfonyl polypeptide guanidinylating agent is adopted in the route, so that ultralow-temperature reaction and the useof trifluoromethanesulfonyl chloride or trifluoromethanesulfonic anhydride with high corrosivity are avoided, and a simple and efficient way is provided for the synthesis of the intermediate.