Methyl 2-(3-nitro-2-oxopyridin-1(2H)-yl)acetate

Base Information

• Chemical Name: Methyl 2-(3-nitro-2-oxopyridin-1(2H)-yl)acetate
• CAS No.: 183666-09-3
• Molecular Formula: C8H8N2O5
• Molecular Weight: 212.16
• Hs Code.: 2933399090
• Mol file: 183666-09-3.mol

Synonyms:1(2H)-Pyridineacetic acid, 3-nitro-2-oxo-, methyl ester; Methyl (3-nitro-2-oxopyridin-1(2H)-yl)acetate

Chemical Property of Methyl 2-(3-nitro-2-oxopyridin-1(2H)-yl)acetate

Chemical Property:

• Vapor Pressure: 3.26E-06mmHg at 25°C
• Boiling Point: 387.6°C at 760 mmHg
• PKA: -5.68±0.70(Predicted)
• Flash Point: 188.2°C
• PSA: 94.12000
• Density: 1.43g/cm³
• LogP: 0.45270
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl 2-(3-nitro-2-oxopyridin-1(2H)-yl)acetate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 2-(3-nitro-2-oxopyridin-1(2H)-yl)acetate

There total 2 articles about Methyl 2-(3-nitro-2-oxopyridin-1(2H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-nitropyridone (6332-56-5) + bromoacetic acid methyl ester (96-32-2) → methyl 2-(3-nitro-2-oxo-1-pyridyl)acetate (183666-09-3)

Guidance literature:

3-nitropyridone; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 1h;

bromoacetic acid methyl ester; for 2h;

Reference yield:

2-hydroxy-3-nitropyridine (6332-56-5) + bromoacetic acid methyl ester (96-32-2) → methyl 2-(3-nitro-2-oxo-1-pyridyl)acetate (183666-09-3)

Guidance literature:

With sodium hydride; Multistep reaction; 1.) DMF;

DOI:10.1016/S0960-894X(97)00220-5

Reference yield:

methyl 2-(3-nitro-2-oxo-1-pyridyl)acetate (183666-09-3) → 3-(2-{3-[(Naphthalene-2-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-acetylamino)-4-oxo-5-phenoxy-pentanoic acid

Guidance literature:

Multi-step reaction with 6 steps

1: H₂ / Pd/C

3: LiOH

4: N-methylmorpholine, EDC

5: Dess-Martin Periodinane

6: TFA / CH₂Cl₂ / 0 °C

With 4-methyl-morpholine; lithium hydroxide; hydrogen; Dess-Martin periodane; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane;

DOI:10.1016/S0960-894X(97)00220-5

upstream raw materials:

2-hydroxy-3-nitropyridine

bromoacetic acid methyl ester

3-nitropyridone

Downstream raw materials:

(3-Amino-2-oxo-2H-pyridin-1-yl)-acetic acid methyl ester

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