2-Hydroxy-3-nitropyridine

Base Information

• Chemical Name: 2-Hydroxy-3-nitropyridine
• CAS No.: 6332-56-5
• Molecular Formula: C5H4N2O3
• Molecular Weight: 140.098
• Hs Code.: 29333990
• European Community (EC) Number: 228-709-2
• NSC Number: 26281
• DSSTox Substance ID: DTXSID20212704
• Nikkaji Number: J926A
• Wikidata: Q72496073
• Mol file: 6332-56-5.mol

Synonyms:2-H-3-NPy;2-hydroxy-3-nitropyridine

Chemical Property of 2-Hydroxy-3-nitropyridine

Chemical Property:

• Appearance/Colour: yellow needle-like crystal
• Vapor Pressure: 1.24E-05mmHg at 25°C
• Melting Point: 212 °C
• Refractive Index: 1.588
• Boiling Point: 368.8 °C at 760 mmHg
• PKA: 8.37±0.10(Predicted)
• Flash Point: 176.9 °C
• PSA: 78.68000
• Density: 1.44 g/cm³
• LogP: 0.80630
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 140.02219199
• Heavy Atom Count: 10
• Complexity: 236

Purity/Quality:

99% ^*data from raw suppliers

3-Nitropyridin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-40
• Safety Statements: 26-36-45-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CNC(=O)C(=C1)[N+](=O)[O-]
• Uses: 2-Hydroxy-3-nitropyridine was used in the synthesis of:3-nitro-2-pyridyl β-D-galactoside3-nitro-2-pyridyl N-acetyl-β-D-glucosaminide5-amino-6-chloro-3-iodopyridine

Technology Process of 2-Hydroxy-3-nitropyridine

There total 11 articles about 2-Hydroxy-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) → 2-hydroxy-3-nitropyridine (6332-56-5)

Guidance literature:

With hydrogenchloride; water; at 112 ℃; for 20h;

DOI:10.1016/j.bmcl.2012.04.095

Reference yield: 87.0%

2-amino-3-nitropyridine (4214-75-9) → 2-hydroxy-3-nitropyridine (6332-56-5)

Guidance literature:

With potassium hydroxide; In water; for 13h; Heating;

DOI:10.1021/jo00342a050

Reference yield: 22.0%

2-Pyridone (142-08-5,1199357-22-6) → 3-nitropyridone (6332-56-5)

Guidance literature:

With sulfuric acid; nitric acid; In water; at 20 - 80 ℃;

DOI:10.1023/A:1013237222718

upstream raw materials:

2-hydroxypyridin

2-amino-3-nitropyridine

2-(methylamino)-3-nitropyridine

2-Pyridone

Downstream raw materials:

1-methyl-3-nitropyridin-2(1H)-one

2-hydroxy-3-aminopyridine

2-Chloro-3-nitropyridine

2-bromo-3-nitropyridine