3-Cyclopropylmethoxy-4-hydroxybenzaldehyde

Base Information

• Chemical Name: 3-Cyclopropylmethoxy-4-hydroxybenzaldehyde
• CAS No.: 25934-52-5
• Molecular Formula: C11H12O3
• Molecular Weight: 192.214
• Hs Code.: 2912499000
• Mol file: 25934-52-5.mol

Synonyms:3-Cyclopropylmethoxy-4-hydroxybenzaldehyde

Chemical Property of 3-Cyclopropylmethoxy-4-hydroxybenzaldehyde

Chemical Property:

• PSA: 46.53000
• LogP: 1.99350
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-(Cyclopropylmethoxy)-4-hydroxybenzaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(cyclopropylmethoxy)-4-hydroxybenzaldehyde is used as a reactant in the preparation of ethyl (alkoxy)?(cyclopropylmethoxy)?-?4-?hydroxy-?3-?quinolinecarboxylates.

Technology Process of 3-Cyclopropylmethoxy-4-hydroxybenzaldehyde

There total 4 articles about 3-Cyclopropylmethoxy-4-hydroxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-(benzyloxy)-3-(cyclopropylmethoxy)benzaldehyde (1381886-14-1) → 3-(cyclopropylmethoxy)-4-hydroxybenzaldehyde (25934-52-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 2h;

Reference yield:

3-bromo-4-hydroxybenzylaldehyde (2973-78-6) → 3-(cyclopropylmethoxy)-4-hydroxybenzaldehyde (25934-52-5)

Guidance literature:

With sodium; In N,N-dimethyl-formamide; at 20 - 110 ℃;

With copper(l) chloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

3-bromo-4-hydroxybenzylaldehyde; at 120 ℃; for 0.5h;

Reference yield:

4-benzyloxy-3-hydroxy-benzaldehyde (4049-39-2) → 3-(cyclopropylmethoxy)-4-hydroxybenzaldehyde (25934-52-5)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 65 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 2 h / 20 °C

With palladium 10% on activated carbon; hydrogen; caesium carbonate; In ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

3-bromo-4-hydroxybenzylaldehyde

4-benzyloxy-3-hydroxy-benzaldehyde

4-(benzyloxy)-3-(cyclopropylmethoxy)benzaldehyde

Downstream raw materials:

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid

3-(cyclopropylmethoxy)-4-(difluoromethoxy)benzoyl chloride

3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzaldehyde

Refernces

• 1、 -. "PERFUME SYSTEMS". Page/Page column 67; 68. . Retrieved 2015/12/08.