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2973-78-6 Usage


3-Bromo-4-hydroxybenzaldehyde is an organic compound that serves as an important intermediate in the synthesis of various organic molecules. It is characterized by the presence of a bromine atom at the 3rd position and a hydroxyl group at the 4th position of a benzene ring, with an aldehyde group attached to the 1st position.


Used in Organic Synthesis:
3-Bromo-4-hydroxybenzaldehyde is used as an intermediate in the production of other chemicals, such as 5-Brom-4-hydroxy-b-nitrostyrol. Its unique structure allows for further chemical reactions and modifications, making it a valuable compound in the field of organic chemistry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-Bromo-4-hydroxybenzaldehyde can be used as a building block for the development of new drugs. Its chemical properties enable it to be a part of various drug molecules, potentially leading to the creation of novel therapeutic agents.
Used in Chemical Research:
3-Bromo-4-hydroxybenzaldehyde is also utilized in chemical research for studying the properties and reactivity of different functional groups. Its unique structure makes it an interesting subject for researchers to explore and understand the underlying chemical mechanisms and reactions.
Used in Dye and Pigment Industry:
3-BROMO-4-HYDROXYBENZALDEHYDE may also find applications in the dye and pigment industry, where it can be used to produce various colors and shades. Its chemical structure allows for the possibility of creating a range of hues, making it a potential candidate for use in this industry.

Check Digit Verification of cas no

The CAS Registry Mumber 2973-78-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,7 and 3 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2973-78:
116 % 10 = 6
So 2973-78-6 is a valid CAS Registry Number.

2973-78-6 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (B24729)  3-Bromo-4-hydroxybenzaldehyde, 97+%   

  • 2973-78-6

  • 5g

  • 354.0CNY

  • Detail
  • Alfa Aesar

  • (B24729)  3-Bromo-4-hydroxybenzaldehyde, 97+%   

  • 2973-78-6

  • 25g

  • 1507.0CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017


1.1 GHS Product identifier


1.2 Other means of identification

Product number -
Other names 2-Bromo-4-formylphenol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2973-78-6 SDS

2973-78-6Relevant articles and documents

Solvolytic Elimination and Hydrolysis promoted by an Aromatic Hydroxy-group. Part 2. The Hydrolysis of 2-Bromo-4-dibromomethylphenol in 95percent 1,4-Dioxane

Mare, Peter B. D. de la,Newman, Paul A.

, p. 1797 - 1802 (1984)

The reaction of 2-bromo-4-dibromomethylphenol with water in slightly aqueous (95percent) 1,4-dioxane has been examined kinetically by using u.v. spectroscopy, which provides evidence for the transient formation of the quinone methide, 2-bromo-4-bromomethylenecyclohexa-2,5-dienone, during the hydrolysis.The final product is 3-bromo-4-hydroxybenzaldehyde.The rate of disappearance of starting material is independent of acidity, but is reduced by added or developing bromide ion.The rate of the loss of bromide ion from the phenol is very much greater than that of the corresponding reaction of 2-bromo-4-dibromomethylanisole under the same conditions.An estimate of the value of ?p-OH+ (-1.36), made by using these relative rates, is larger than the value (-0.92) based on relative rates of aromatic electrophilic substitution.Solvent kinetic isotope effects on these reactions are reported; the theoretical implications of variation in the substituent parameter for the hydroxy-group is discussed in terms of solvent effects on H-O hyperconjugation.

Ni-NiO heterojunctions: a versatile nanocatalyst for regioselective halogenation and oxidative esterification of aromatics

Bhardwaj, Nivedita,Goel, Bharat,Indra, Arindam,Jain, Shreyans K.,Singh, Ajit Kumar,Tripathi, Nancy

, p. 14177 - 14183 (2021/08/16)

Herein, we report a facile method for the synthesis of Ni-NiO heterojunction nanoparticles, which we utilized for the nuclear halogenation reaction of phenol and substituted phenols usingN-bromosuccinimide (NBS). A remarkablepara-selectivity was achieved for the halogenated products under semi-aqueous conditions. Interestingly, blocking of thepara-position of phenol offeredortho-selective halogenation. In addition, the Ni-NiO nanoparticles catalyzed the oxidative esterification of carbonyl compounds with alcohol, diol or dithiol in the presence of a catalytic amount of NBS. It was observed that the aromatic carbonyls substituted with an electron-donating group favoured nuclear halogenation, whereas an electron-withdrawing group substitution in carbonyl compounds facilitated the oxidation reaction. In addition, the catalyst was magnetically separated and recycled 10 times. The tuned electronic structure at the Ni-NiO heterojunction controlled selectivity and activity as no suchpara-selectivity was observed with commercially available NiO or Ni nanoparticles.

Structure-Activity-Relationship-Aided Design and Synthesis of xCT Antiporter Inhibitors

Cirillo, Davide,Sarowar, Shahin,?yvind Enger, Per,Bj?rsvik, Hans-René

, p. 2650 - 2668 (2021/06/01)

The xCT antiporter is a cell membrane protein involved in active counter-transportation of glutamate (outflux) with cystine (influx) over the human cell membrane. This feature makes the xCT antiporter a crucial element of the biosynthesis of the vital free radical scavenger glutathione. The prodrug sulfasalazine, a medication for the treatment of ulcerative colitis, was previously proven to inhibit the xCT antiporter. Starting from sulfasalazine, a molecular scaffold jumping followed by SAR-assisted design and synthesis provided a series of styryl hydroxy-benzoic acid analogues that were biologically tested in vitro for their ability to decrease intracellular glutathione levels using four different cancer cell lines: A172 (glioma), A375 (melanoma), U87 (glioma) and MCF7 (breast carcinoma). Depletion of glutathione levels varied among the compounds as well as among the cell lines. Flow cytometry using propidium iodide and the annexin V marker demonstrated minimal toxicity in normal human astrocytes for a promising candidate molecule (E)-5-(2-([1,1′-biphenyl]-4-yl)vinyl)-2-hydroxybenzoic acid.

Preparation method of 3-bromo-4-hydroxybenzaldehyde


Paragraph 0036; 0041; 0042, (2020/02/19)

The invention discloses a preparation method of 3-bromo-4-hydroxybenzaldehyde. The preparation method comprises the following steps: (1) carrying out a bromination reaction on p-hydroxybenzene methylal and bromine to obtain 3-bromo-4-hydroxybenzene methylal; and (2) carrying out a hydrolysis reaction on the 3-bromo-4-hydroxybenzene methylal obtained in the step (1), and carrying out post-treatmentafter the reaction is finished to obtain the 3-bromo-4-hydroxybenzaldehyde. According to the preparation method, aldehyde is replaced with acetal for the bromination reaction, so that generation of adibromo product is effectively avoided, the yield and purity of a monobromo product are improved, and industrialization is facilitated.

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