(2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid

Base Information Edit

Chemical Name:(2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid
CAS No.:120205-50-7
Molecular Formula:C14H25NO5
Molecular Weight:287.356
Hs Code.:2933998090
European Community (EC) Number:808-466-4
DSSTox Substance ID:DTXSID60452743
Nikkaji Number:J628.822G
Wikidata:Q76416499
Mol file:120205-50-7.mol

Synonyms:120205-50-7;(2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid;BOC-DAP;N-Boc-dolaproine;(2R,3R)-BOC-dolaproine;(2R,3R)-3-((S)-1-(tertbutoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid;(2R,3R)-3-methoxy-2-methyl-3-[(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidin-2-yl]propanoic acid;((2R,3R)-3-((S)-1-(tertbutoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid;(2R,3R)-3-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-3-methoxy-2-methylpropanoic acid;MFCD18157735;SCHEMBL903564;DTXSID60452743;LNEHHTWYEBGHBY-OUAUKWLOSA-N;AMY30680;CS-B0750;VEA20550;AKOS016012593;AKOS016016040;DS-5307;BP-20231;J-500005;(2R,3R)-3-((S)-1-(t-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanic acid

Suppliers and Price of (2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2R,3R)-BOC-dolaproine
500mg
$ 5445.00

TRC
(2R,3R)-BOC-dolaproine
200mg
$ 3520.00

Medical Isotopes, Inc.
(2R,3R)-BOC-dolaproine
500 mg
$ 5950.00

Crysdot
Boc-Dap 95+%
250mg
$ 200.00

Crysdot
Boc-Dap 95+%
100mg
$ 125.00

Crysdot
Boc-Dap 95+%
1g
$ 500.00

ChemScene
N-Boc-dolaproine 99.87%
5g
$ 760.00

ChemScene
N-Boc-dolaproine 99.87%
1g
$ 216.00

Chemenu
Boc-Dap 95%
1g
$ 468.00

Apolloscientific
(2R,3R)-3-((S)-1-(tert-Butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid
250mg
$ 1264.00

Total 53 raw suppliers

Chemical Property of (2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid Edit

Chemical Property:

Boiling Point:397.8±17.0 °C(Predicted)
PKA:4.27±0.11(Predicted)
PSA：76.07000
Density:1.133±0.06 g/cm3(Predicted)
LogP:2.05950
Storage Temp.:2-8°C
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:287.17327290
Heavy Atom Count:20
Complexity:363

Purity/Quality:

98% ^*data from raw suppliers

(2R,3R)-BOC-dolaproine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(C1CCCN1C(=O)OC(C)(C)C)OC)C(=O)O
Isomeric SMILES:C[C@H]([C@H]([C@@H]1CCCN1C(=O)OC(C)(C)C)OC)C(=O)O
Uses (2R,3R)-BOC-dolaproine is an β-methoxy-γ-amino acid component of dolastatin 10, an antineoplastic agent.

Technology Process of (2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid

There total 50 articles about (2R,3R)-3-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-3-methoxy-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: (S)-t-butyl 2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-((R)-2-oxo-4-phenyloxazolidin-3-yl)propyl)pyrrolidine-1-carboxylate

: 120205-50-7
N-Boc-(2R,3R,4S)-dolaproine

Guidance literature:: (S)-t-butyl 2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-((R)-2-oxo-4-phenyloxazolidin-3-yl)propyl)pyrrolidine-1-carboxylate; With dihydrogen peroxide; lithium hydroxide; In tetrahydrofuran; at 0 ℃; for 3h;

With sodium sulfite; In tetrahydrofuran; at 20 - 25 ℃; for 16h;

Reference yield: 98.0%

: 180715-99-5
(4R,5S,2'R,3'R,2S)-3-[3'-(N-tert-butoxycarbonyl-2-pyrrolidinyl)-3'-methoxy-2'-methylpropanoyl]-4-methyl-5-phenyl-2-oxazolidinone

: 120205-50-7
N-Boc-(2R,3R,4S)-dolaproine

Guidance literature:: (4R,5S,2'R,3'R,2"S)-3-[3'-(N-tert-butoxycarbonyl-2"-pyrrolidinyl)-3'-methoxy-2'-methylpropanoyl]-4-methyl-5-phenyl-2-oxazolidinone; With dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 0.0833333h;

With water; lithium hydroxide; In tetrahydrofuran; at 0 ℃; for 3h;