(2S,1'R,2'S)-N-(tert-butoxycarbonyl)- 2-(1'-Methoxy-2'-Methyl-3'-butenyl)- pyrrolidine

Base Information

Chemical Name:(2S,1'R,2'S)-N-(tert-butoxycarbonyl)- 2-(1'-Methoxy-2'-Methyl-3'-butenyl)- pyrrolidine
CAS No.:159173-43-0
Molecular Formula:C15H27NO3
Molecular Weight:269.384
Hs Code.:
Mol file:159173-43-0.mol

Synonyms:tert-butyl (2S)-2-[(1R,2S)-1-methoxy-2-methylbut-3-en-1-yl]pyrrolidine-1-carboxylate;(2S,1R,2S)-N-(tert-butoxycarbonyl)-2-(1-Methoxy-2-Methyl-3-butenyl)-pyrrolidine;

Suppliers and Price of (2S,1'R,2'S)-N-(tert-butoxycarbonyl)- 2-(1'-Methoxy-2'-Methyl-3'-butenyl)- pyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of (2S,1'R,2'S)-N-(tert-butoxycarbonyl)- 2-(1'-Methoxy-2'-Methyl-3'-butenyl)- pyrrolidine

Chemical Property:

Boiling Point:328.1±25.0 °C(Predicted)
PKA:-2.10±0.40(Predicted)
PSA：38.77000
Density:0.996±0.06 g/cm3(Predicted)
LogP:3.16090

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2S,1'R,2'S)-N-(tert-butoxycarbonyl)- 2-(1'-Methoxy-2'-Methyl-3'-butenyl)- pyrrolidine

There total 6 articles about (2S,1'R,2'S)-N-(tert-butoxycarbonyl)- 2-(1'-Methoxy-2'-Methyl-3'-butenyl)- pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 159173-40-7
(2S,1'R,2'S)-N-(tert-butoxycarbonyl)-2-(1'-hydroxy-2'-methyl-3'-butenyl)-pyrrolidine

: 74-88-4
methyl iodide

: 159173-43-0
(2S,1'R,2'S)-N-(tert-butoxycarbonyl)-2-(1'-methoxy-2'-methyl-3'-butenyl)-pyrrolidine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 3.66667h; Inert atmosphere;
DOI:10.1016/j.tet.2017.03.006

Reference yield:

: ammonium chloride

: 74-88-4
methyl iodide

: 159173-43-0
(2S,1'R,2'S)-N-(tert-butoxycarbonyl)-2-(1'-methoxy-2'-methyl-3'-butenyl)-pyrrolidine

Guidance literature:: In hexane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 69610-41-9,117625-90-8
Boc-L-Pro-H

: 159173-43-0
(2S,1'R,2'S)-N-(tert-butoxycarbonyl)-2-(1'-methoxy-2'-methyl-3'-butenyl)-pyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / tetrahydrofuran / 3 h / Ambient temperature

2: 90 percent / NaH / dimethylformamide / 24 h / Ambient temperature

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)80692-X