3-AzetidinecarboxaMide HCl

Base Information

• Chemical Name: 3-AzetidinecarboxaMide HCl
• CAS No.: 124668-45-7
• Molecular Formula: C4H9ClN2O
• Molecular Weight: 136.5801
• Hs Code.: 2933990090
• Mol file: 124668-45-7.mol

Synonyms:3-AzetidinecarboxaMide HCl

Chemical Property of 3-AzetidinecarboxaMide HCl

Chemical Property:

• PSA: 56.11000
• LogP: 0.97160
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Azetidine-3-carboxamideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AzetidinecarboxaMide HCl

There total 1 articles about 3-AzetidinecarboxaMide HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-cyanoazetidine-1-carboxylate (142253-54-1) → azetidine-3-carboxamide hydrochloride (124668-45-7) + azetidine-3-carbonitrile hydrochloride (345954-83-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 2h; Overall yield = 99 %; Overall yield = 0.13 g;

Reference yield: 9.5%

azetidine-3-carboxamide hydrochloride (124668-45-7) + N-(3-(4-amino-7-(cis-3-formylcyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzyl)methanesulfonamide → 1-((cis-3-(4-amino-5-(3-(methylsulfonamidomethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclobutyl)methyl)azetidine-3-carboxamide

Guidance literature:

azetidine-3-carboxamide hydrochloride; With N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; at 20 ℃; for 0.0833333h;

N-(3-(4-amino-7-(cis-3-formylcyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzyl)methanesulfonamide; With acetic acid; In methanol; dichloromethane; at 20 ℃; for 0.5h;

With methanol; sodium cyanoborohydride; In dichloromethane; at 20 ℃; for 24h;

Reference yield: 4.1%

azetidine-3-carboxamide hydrochloride (124668-45-7) + N-(3-(4-amino-7-(trans-3-formylcyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzyl)methanesulfonamide → 1-((trans-3-(4-amino-5-(3-(methylsulfonamidomethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclobutyl)methyl)azetidine-3-carboxamide

Guidance literature:

azetidine-3-carboxamide hydrochloride; With acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; at 20 ℃; for 0.0833333h;

N-(3-(4-amino-7-(trans-3-formylcyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzyl)methanesulfonamide; With acetic acid; In methanol; dichloromethane; at 20 ℃; for 0.5h;

With methanol; sodium cyanoborohydride; In dichloromethane; at 20 ℃; for 16h;

upstream raw materials:

tert-butyl 3-cyanoazetidine-1-carboxylate

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