1-Boc-3-cyanoazetidine

Base Information Edit

Chemical Name:1-Boc-3-cyanoazetidine
CAS No.:142253-54-1
Molecular Formula:C9H14N2O2
Molecular Weight:182.222
Hs Code.:2933990090
European Community (EC) Number:640-760-6
DSSTox Substance ID:DTXSID90442692
Wikidata:Q70000082
Mol file:142253-54-1.mol

Synonyms:1-Boc-3-cyanoazetidine;142253-54-1;Tert-butyl 3-cyanoazetidine-1-carboxylate;1-n-boc-3-cyano-azetidine;1-(n-boc)-3-cyanoazetidine;1-N-Boc-3-cyanoazetidine;MFCD06796640;1-AZETIDINECARBOXYLIC ACID, 3-CYANO-, 1,1-DIMETHYLETHYL ESTER;3-CYANO-1-BOC-AZETIDINE;1-n-boc-3-cyano azetidine;3-Cyano-azetidine-1-carboxylic acid tert-butyl ester;n-boc-3-cyanoazetidine;n-t-boc-3-cyanoazetidine;SCHEMBL28392;DTXSID90442692;WEFREESWPHICPL-UHFFFAOYSA-N;1-(t-butoxycarbonyl)-3-cyanoazetidine;AKOS005258615;AC-2223;PB21991;Tert-butyl3-cyanoazetidine-1-carboxylate;1-(N-Boc)-3-cyanoazetidine, AldrichCPR;1-(tert-butoxycarbonyl)-3-cyanoazetidine;azetidine-3-carbonitrile, n-boc protected;SY018068;tert-butyl-3-cyanoazetidine-1-carboxylate;TS-02541;AM20080321;CS-0001914;FT-0645813;EN300-80920;B66744;3-cyanoazetidine-1-carboxylic acid tert-butyl ester;1-Boc-azetidine-3-carbonitrile tert-Butyl 3-cyanoazetidine-1-carboxylate

Suppliers and Price of 1-Boc-3-cyanoazetidine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-?(N-?Boc)?-?3-?cyanoazetidine
10g
$ 250.00

Synthonix
1-(N-BOC)-3-cyanoazetidine 97.0%
1g
$ 15.00

Synthonix
1-(N-BOC)-3-cyanoazetidine 97.0%
5g
$ 40.00

SynQuest Laboratories
Azetidine-3-carbonitrile, N-Boc protected
5 g
$ 138.00

SynQuest Laboratories
Azetidine-3-carbonitrile, N-Boc protected
25 g
$ 350.00

SynQuest Laboratories
Azetidine-3-carbonitrile, N-Boc protected
1 g
$ 88.00

Sigma-Aldrich
1-(N-Boc)-3-cyanoazetidine Aldrich
1g
$ 68.30

Matrix Scientific
1-(N-Boc)-3-cyanoazetidine 98%
5g
$ 105.00

Matrix Scientific
1-(N-Boc)-3-cyanoazetidine 98%
1g
$ 38.00

Matrix Scientific
1-(N-Boc)-3-cyanoazetidine 98%
25g
$ 394.00

Total 85 raw suppliers

Chemical Property of 1-Boc-3-cyanoazetidine Edit

Chemical Property:

Vapor Pressure:0.002mmHg at 25°C
Melting Point:68-71 °C
Refractive Index:1.49
Boiling Point:290.154 °C at 760 mmHg
PKA:-4.29±0.40(Predicted)
Flash Point:129.281 °C
PSA：53.33000
Density:1.113 g/cm³
LogP:1.31478
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:0.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:182.105527694
Heavy Atom Count:13
Complexity:253

Purity/Quality:

99% ^*data from raw suppliers

1-?(N-?Boc)?-?3-?cyanoazetidine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn, Xi
Hazard Codes:Xi,Xn
Statements: 20/21/22-36/37/38-52-36-22
Safety Statements: 26-36/37/39-36/37-9

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CC(C1)C#N
Uses 1-?(N-?Boc)?-?3-?cyanoazetidine can be used as reagent/reactant for preparation and SAR of pyridinylmethanol derivatives as TRPV3 antagonists. It can also be used as reagent/reactant for preparation of substituted pyridines via nucleophilic aromatic substitution of cyanopyridines with disubstituted esters and nitriles.

Technology Process of 1-Boc-3-cyanoazetidine

There total 7 articles about 1-Boc-3-cyanoazetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%