(R)-1-(thiazol-2-yl)ethanaMine hydrochloride

Base Information

• Chemical Name: (R)-1-(thiazol-2-yl)ethanaMine hydrochloride
• CAS No.: 623143-43-1
• Molecular Formula: C5H8N2S
• Molecular Weight: 164.65636
• Hs Code.: 2934100090
• Mol file: 623143-43-1.mol

Synonyms:(R)-1-(thiazol-2-yl)ethanaMine hydrochloride;(R)-1-(THIAZOL-2-YL)ETHANAMINE HCL;(R)-1-(Thiazol-2-yl)ethanaMine

Chemical Property of (R)-1-(thiazol-2-yl)ethanaMine hydrochloride

Chemical Property:

• PSA: 67.15000
• LogP: 2.66510

Purity/Quality:

98% ^*data from raw suppliers

(R)-1-(Thiazol-2-yl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-(thiazol-2-yl)ethanaMine hydrochloride

There total 10 articles about (R)-1-(thiazol-2-yl)ethanaMine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.1%

N-benzhydryl-(1R)-1-(thiazol-2-yl)ethanamine → (1R)-1-(thiazol-2-yl)ethanamine (623143-43-1)

Guidance literature:

With N-Bromosuccinimide; In water; acetonitrile; at 20 ℃; for 7h;

Reference yield:

2-Acetylthiazole (24295-03-2,260998-74-1) → (1R)-1-(thiazol-2-yl)ethanamine (623143-43-1)

Guidance literature:

With pyridoxal 5'-phosphate; isopropylamine; In dimethyl sulfoxide; at 30 ℃; for 24h; pH=7.5; Reagent/catalyst; Enzymatic reaction;

DOI:10.1021/op4003104

Reference yield:

(1S,2S,5S)-2,6,6-Trimethyl-3-[(E)-(R)-1-thiazol-2-yl-ethylimino]-bicyclo[3.1.1]heptan-2-ol (179077-92-0) → (1R)-1-(thiazol-2-yl)ethanamine (623143-43-1)

Guidance literature:

With sodium hydroxide; hydroxylamine hydrochloride; acetic acid; In methanol; at 0 ℃; for 5h;

DOI:10.1055/s-1996-4259

upstream raw materials:

2,4-Dinitrofluorobenzene

dysidenin

isodysidenin

(1S,2S,5S)-2,6,6-Trimethyl-3-[(E)-(R)-1-thiazol-2-yl-ethylimino]-bicyclo[3.1.1]heptan-2-ol

Downstream raw materials:

(2,4-Dinitro-phenyl)-((R)-1-thiazol-2-yl-ethyl)-amine

(R)-5,5,5-Trichloro-2-[(2,4-dinitro-phenyl)-methyl-amino]-4-methyl-pentanoic acid

(S)-5,5,5-Trichloro-2-[(2,4-dinitro-phenyl)-methyl-amino]-4-methyl-pentanoic acid

Refernces

• 1、 -. "METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND". . . Retrieved 2020/11/27.
• 2、 Dondoni, Alessandro,Merchan, Francisco L.,Merino, Pedro,Rojo, Isabel,Tejero, Tomas. "Alkylation of camphor and pinanone imines of 2-(aminomethyl)thiazole. Enantioselective synthesis of 2-(1-aminoalkyl)thiazoles". . p. 641 - 646. Retrieved 2007/10/03.