Phosphoramidous acid, bis(1-methylethyl)-, (1S)-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(7,9-dimethyl-4-oxopyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3(4H)-yl)propyl 2-cyanoethyl ester(9CI)

Base Information

Chemical Name:Phosphoramidous acid, bis(1-methylethyl)-, (1S)-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(7,9-dimethyl-4-oxopyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3(4H)-yl)propyl 2-cyanoethyl ester(9CI)
CAS No.:548430-99-5
Molecular Formula:C45H52N5O6PS
Molecular Weight:821.96
Hs Code.:
Mol file:548430-99-5.mol

Phosphoramidous acid, bis(1-methylethyl)-, (1S)-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(7,9-dimethyl-4-oxopyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3(4H)-yl)propyl 2-cyanoethyl ester(9CI)

Synonyms:Bis(1-methylethyl)phosphoramidous acid (1S)-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(7,9-dimethyl-4-oxopyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3(4H)-yl)propyl 2-cyanoethyl ester;Phosphoramidous acid, bis(1-methylethyl)-, (1S)-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(7,9-dimethyl-4-oxopyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3(4H)-yl)propyl 2-cyanoethyl ester(9CI)

Suppliers and Price of Phosphoramidous acid, bis(1-methylethyl)-, (1S)-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(7,9-dimethyl-4-oxopyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3(4H)-yl)propyl 2-cyanoethyl ester(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 3 raw suppliers

Chemical Property of Phosphoramidous acid, bis(1-methylethyl)-, (1S)-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(7,9-dimethyl-4-oxopyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3(4H)-yl)propyl 2-cyanoethyl ester(9CI)

Chemical Property:

Boiling Point:854.9±75.0 °C(Predicted)
PKA:7.29±0.20(Predicted)
PSA：162.79000
LogP:10.01070

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Phosphoramidous acid, bis(1-methylethyl)-, (1S)-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(7,9-dimethyl-4-oxopyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3(4H)-yl)propyl 2-cyanoethyl ester(9CI)

There total 4 articles about Phosphoramidous acid, bis(1-methylethyl)-, (1S)-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(7,9-dimethyl-4-oxopyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3(4H)-yl)propyl 2-cyanoethyl ester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 548430-98-4
3-{(S)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-hydroxy-butyl}-7,9-dimethyl-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 548430-99-5
Diisopropyl-phosphoramidous acid (S)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(7,9-dimethyl-4-oxo-4H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3-yl)-propyl ester 2-cyano-ethyl ester

Guidance literature:: With N,N-diisopropylamine tetrazolide; In dichloromethane;
DOI:10.1081/NCN-120027829

Reference yield:

: 548430-97-3
3-((S)-3,4-Dihydroxy-butyl)-7,9-dimethyl-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one

: 548430-99-5
Diisopropyl-phosphoramidous acid (S)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(7,9-dimethyl-4-oxo-4H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3-yl)-propyl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / pyridine / 20 °C

2: 84 percent / N,N-diisopropylammonium tetrazolide / CH₂Cl₂

With pyridine; N,N-diisopropylamine tetrazolide; In dichloromethane;
DOI:10.1081/NCN-120027829

Reference yield:

: 548430-96-2
3-[2-((S)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-ethyl]-7,9-dimethyl-3H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-one

: 548430-99-5
Diisopropyl-phosphoramidous acid (S)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(7,9-dimethyl-4-oxo-4H-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3-yl)-propyl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / aq. AcOH / 24 h / 20 °C

2: 65 percent / pyridine / 20 °C

3: 84 percent / N,N-diisopropylammonium tetrazolide / CH₂Cl₂

With pyridine; N,N-diisopropylamine tetrazolide; acetic acid; In dichloromethane;
DOI:10.1081/NCN-120027829