Benzenepropanoic acid, 2-fluoro-4-methoxy-, methyl ester

Base Information

Chemical Name:Benzenepropanoic acid, 2-fluoro-4-methoxy-, methyl ester
CAS No.:874187-38-9
Molecular Formula:C₁₁H₁₃FO₃
Molecular Weight:212.221
Hs Code.:
Mol file:874187-38-9.mol

Synonyms:Reaxys ID: 9847689;methyl 3-(2-fluoro-4-methoxyphenyl)propanoate;Benzenepropanoic acid, 2-fluoro-4-Methoxy-, Methyl ester

Suppliers and Price of Benzenepropanoic acid, 2-fluoro-4-methoxy-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methyl3-(2-fluoro-4-methoxyphenyl)propanoate
100mg
$ 240.00

Crysdot
Methyl3-(2-fluoro-4-methoxyphenyl)propanoate 95+%
1g
$ 451.00

Total 5 raw suppliers

Chemical Property of Benzenepropanoic acid, 2-fluoro-4-methoxy-, methyl ester

Chemical Property:

PSA：35.53000
LogP:1.93990

Purity/Quality:

98% ^*data from raw suppliers

Methyl3-(2-fluoro-4-methoxyphenyl)propanoate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzenepropanoic acid, 2-fluoro-4-methoxy-, methyl ester

There total 2 articles about Benzenepropanoic acid, 2-fluoro-4-methoxy-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 331-64-6
2-fluoro-4-methoxy-benzaldehyde

: 874187-38-9
3-(2-fluoro-4-methoxy-phenyl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.58 h / 0 - 20 °C

1.2: 75 percent / dimethylformamide / 20 h / 20 °C

2.1: H₂ / Pd/C / methanol / 20 h

With hydrogen; sodium hydride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; 1.2: Horner-Emmons reaction;
DOI:10.3390/90600449

Reference yield:

: 852181-14-7
3-(2-fluoro-4-methoxyphenyl)acrylic acid methyl ester

: 874187-38-9
3-(2-fluoro-4-methoxy-phenyl)-propionic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 20h;
DOI:10.3390/90600449

Reference yield:

: 874187-38-9
3-(2-fluoro-4-methoxy-phenyl)-propionic acid methyl ester

: 3-(2-fluoro-4-methoxy-phenyl)-propionyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: 8.2 g / aq. NaOH / 3 h / Heating

2: SOCl₂ / dimethylformamide / 1 h / Heating

With sodium hydroxide; thionyl chloride; In N,N-dimethyl-formamide;
DOI:10.3390/90600449