2-(Bromomethyl)-5-fluoropyridine

Base Information

• Chemical Name: 2-(Bromomethyl)-5-fluoropyridine
• CAS No.: 954225-35-5
• Molecular Formula: C6H5BrFN
• Molecular Weight: 190.015
• Hs Code.: 2933399090
• Mol file: 954225-35-5.mol

Synonyms:2-(bromomethyl)-5-fluoropyridine;2-(bromomethyl)-5-fluoropyridine hydrochloride;Pyridine, 2-(bromomethyl)-5-fluoro-

Chemical Property of 2-(Bromomethyl)-5-fluoropyridine

Chemical Property:

• Vapor Pressure: 0.662mmHg at 25°C
• Boiling Point: 193℃
• Flash Point: 71℃
• PSA: 12.89000
• Density: 1.632
• LogP: 2.11560
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(bromomethyl)-5-fluoropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Bromomethyl)-5-fluoropyridine

There total 1 articles about 2-(Bromomethyl)-5-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2‐methyl‐5‐fluoropyridine (31181-53-0) → 2-(bromomethyl)-5-fluoropyridine (954225-35-5)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 2h; Reflux;

DOI:10.1021/acs.jmedchem.0c00127

Reference yield: 89.0%

2-(bromomethyl)-5-fluoropyridine (954225-35-5) + triphenylphosphine (603-35-0) → (5-fluoropyrid-2-yl)methyltriphenylphosphonium bromide (1595287-23-2)

Guidance literature:

In toluene; for 12h; Reflux;

DOI:10.1021/acs.jmedchem.0c00127

Reference yield: 61.0%

2-(bromomethyl)-5-fluoropyridine (954225-35-5) + (S)-methyl 2-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)benzoate → (S)-methyl 2-(3-((5-fluoropyridin-2-yl)methoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoate

Guidance literature:

(S)-methyl 2-(3-hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)benzoate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1h;

2-(bromomethyl)-5-fluoropyridine; In N,N-dimethyl-formamide; mineral oil; at 0 - 50 ℃; for 22h;

DOI:10.1016/j.bmc.2013.10.023

upstream raw materials:

2‐methyl‐5‐fluoropyridine

Downstream raw materials:

1-(2-(4-((dimethylamino)methyl)-2-methylphenyl)-2-oxoethyl)-4-((5-fluoropyridin-2-yl)methoxy)pyridin-2(1H)-one

4-(5-fluoro-pyridin-2-ylmethoxy)-1-[2-(4-hydroxymethyl-2-methyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one

1-[2-(4-bromomethyl-2-methyl-phenyl)-2-oxo-ethyl]-4-(5-fluoro-pyridin-2-ylmethoxy)-1H-pyridin-2-one

(5-fluoropyrid-2-yl)methyltriphenylphosphonium bromide