31181-53-0

Basic information

• Product Name: 5-Fluoro-2-methylpyridine
• Synonyms: 5-FLUORO-2-METHYLPYRIDINE;5-FLUORO-2-PICOLINE;3-FLUORO-6-METHYLPYRIDINE;3-FLUORO-6-PICOLINE;2-methyl-5-fluoro-pyridine;3-FLUORO-6-METHYLPYRIDINE (3-FLUORO-6-PICOLINE);5-FLUORO-2-METHYLPYRIDINE (5-FLUORO-2-PICOLINE);5-FLUORO-2-PICOLINE5-FLUORO-2-METHYLPYRIDINE
• CAS NO: 31181-53-0
• Molecular Formula: C₆H₆FN
• Molecular Weight: 111.12
• Product Categories: Pyridine;Pyridines
• Mol File: 31181-53-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 135-136 C
• Flash Point: 23.1 °C
• Appearance: /
• Density: 1.077 g/cm³
• Vapor Pressure: 23.4mmHg at 25°C
• Refractive Index: 1.477
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.53±0.10(Predicted)
• CAS DataBase Reference: 5-Fluoro-2-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Fluoro-2-methylpyridine(31181-53-0)
• EPA Substance Registry System: 5-Fluoro-2-methylpyridine(31181-53-0)

Safety Data

• Hazard Codes: T,Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 31181-53-0(Hazardous Substances Data)

Usage

General Description

5-Fluoro-2-methylpyridine is a chemical compound that belongs to the class of organic compounds known as fluoropyridines. It has the molecular formula C6H6FN and is identified by its CAS registry number, 393-52-2. This substance appears as a clear, colorless liquid and is primarily used in research and development laboratories, specifically as a starting material or intermediate in the synthesis of more complex chemical substances. 5-Fluoro-2-methylpyridine has a strong, unpleasant odor and may cause harm if improperly handled or consumed, hence, it should be dealt with under the guidelines of appropriate safety precautions.

InChI:InChI=1/C6H6FN/c1-5-2-3-6(7)4-8-5/h2-4H,1H3

Upstream product

• 80287-53-2 5-Amino-2-methylpyridine 

Downstream Products

• 954225-35-5 2-(bromomethyl)-5-fluoropyridine 
• 107504-08-5 5-fluoropicolinic acid 
• 113209-88-4 5-fluoro-2-methyl-4-nitropyridine 1-oxide 
• 113209-90-8 4-chloro-5-fluoro-2-(hydroxymethyl)pyridine 
• 113209-89-5 4-chloro-5-fluoro-2-methylpyridin-1-ium-1-olate 
• 45673-79-8 2‐methyl‐5‐fluoropyridine 1‐oxide 

Relevant articles and documents

BICYCLIC PROLINE COMPOUNDS

The invention is concerned with the compounds of formula (I) and salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

METHOD FOR AROMATIC FLUORINATION

Disclosed is a fluorination method comprising providing an aryl fluorosuifonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosuifonate and the fluorinating reagent to provide a fluorinated aryl species. Also disclosed is a fluorination method comprising providing, a salt comprising a cation and an aryloxyiate, and SO2F2 to a reaction mixture; reacting the SO2F2 and the ammonium salt to provide a fluorinated aryl species. Further disclosed a fluorination method comprising providing a compound having the structure Ar-OH to a reaction mixture; where A is an aryl or heteroaryl; providing SO2F2 to the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SO2F2, the fluorinating reagent and the compound having the structure Ar-OH to provide a fluorinated aryl species having the structure Ar-F.

2- [ (2-SUBSTITUTED) -IND0LIZIN-3-YL] -2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS

The invention provides compounds of formula (I), and pharmaceutically acceptable salts thereof wherein: Rl, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. These compounds are useful in the manufacture of medicaments for use in the prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.