(11aS)-3,7-Bis[3,5-bis(trifluoromethyl)phenyl]-10,11,12,13-tetrahydro-5-hydroxy-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin 5-oxide

Base Information

• Chemical Name: (11aS)-3,7-Bis[3,5-bis(trifluoromethyl)phenyl]-10,11,12,13-tetrahydro-5-hydroxy-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin 5-oxide
• CAS No.: 1258327-07-9
• Molecular Formula: C₃₃H₁₉F₁₂O₄P
• Molecular Weight: 738.466
• Mol file: 1258327-07-9.mol

Synonyms:(11aS)-5-oxide-3,7-bis[3,5-bis(trifluoroMethyl)phenyl]-10,11,12,13-tetrahydro-5-hydroxy-Diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin;(11aS)-3,7-Bis[3,5-bis(trifluoromethyl)phenyl]-10,11,12,13-tetrahydro-5-hydroxy-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin 5-oxide;(11aS)-3,7-Bis[3,5-bis(trifluoromethyl)phenyl]-10,11,12, 13-tetrahydro-5-hydroxy-5-oxide-diindeno[7,1-de:1',7'-fg] [1,3,2]dioxaphosphocin;Diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin, 3,7-bis[3,5-bis(trifluoromethyl)phenyl]-10,11,12,13-tetrahydro-5-hydroxy-, 5-oxide, (11aS)-;(11AS)-3,7-BIS[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-10,11,12,13-TETRAHYDRO-5-HYDROXY-5-OXIDE-DIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN,MIN.98%;(11aS)-3,7-Bis[3,5-bis(trifluoromethyl)phenyl]-10,11,12,13-tetrahydro-5-hydroxy-5-oxide-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin,99%e.e.;(11aS)-3,7-Bis[3,5-bis(trifluoromethyl)phenyl]-10,11,12,13-tetrahydro-5-hydroxy-5-oxide-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin, min. 98%

Chemical Property of (11aS)-3,7-Bis[3,5-bis(trifluoromethyl)phenyl]-10,11,12,13-tetrahydro-5-hydroxy-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin 5-oxide

Chemical Property:

• Melting Point: >300℃
• Boiling Point: 642.3±65.0 °C(Predicted)
• PKA: 1.13±0.20(Predicted)
• PSA: 65.57000
• Density: 1.64±0.1 g/cm3 (20 oC 760 Torr)
• LogP: 11.14590

Purity/Quality:

98.5% ^*data from raw suppliers

(11aS)-3,7-Bis[3,5-bis(trifluoromethyl)phenyl]-10,11,12,13-tetrahydro-5-hydroxy-5-oxide-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin, min. 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (11aS)-3,7-Bis[3,5-bis(trifluoromethyl)phenyl]-10,11,12,13-tetrahydro-5-hydroxy-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin 5-oxide

There total 4 articles about (11aS)-3,7-Bis[3,5-bis(trifluoromethyl)phenyl]-10,11,12,13-tetrahydro-5-hydroxy-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin 5-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-6,6'-bis[3,5-bistrifluoromethylphenyl]-2,2',3,3'-4H-1,1'-spiro bis[1H-indole]-7,7'-diphenol → C33H19F12O4P (1297613-76-3,1258327-07-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; trichlorophosphate / Inert atmosphere

2: hydrogenchloride; water; acetic acid / 1,2-dichloro-ethane / Reflux

With pyridine; hydrogenchloride; water; acetic acid; trichlorophosphate; In 1,2-dichloro-ethane;

DOI:10.1021/jo200302x

Reference yield:

(R)-6,6'-dibromo-2,2',3,3'-tetrahydro-1,1'-spirobis[1H-indole]-7,7'-diphenol (1621066-74-7,1807777-59-8) → C33H19F12O4P (1297613-76-3,1258327-07-9)

Guidance literature:

Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate / 1,4-dioxane; toluene / 105 - 110 °C / Inert atmosphere

2: pyridine; trichlorophosphate / Inert atmosphere

3: hydrogenchloride; water; acetic acid / 1,2-dichloro-ethane / Reflux

With pyridine; hydrogenchloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; acetic acid; trichlorophosphate; In 1,4-dioxane; 1,2-dichloro-ethane; toluene;

DOI:10.1021/jo200302x

Reference yield:

C33H18ClF12O3P → C33H19F12O4P (1297613-76-3,1258327-07-9)

Guidance literature:

With hydrogenchloride; water; acetic acid; In 1,2-dichloro-ethane; Reflux;

DOI:10.1021/jo200302x

upstream raw materials:

(R)-6,6'-dibromo-2,2',3,3'-tetrahydro-1,1'-spirobis[1H-indole]-7,7'-diphenol

Refernces