1H-Indole-4-carboxamide, N,N'-[1,2-ethanediylbis(oxy-3,1-propanediyl)]bis[1-[5-[(2S)-1-(N-methyl-L-alanyl-L-valyl)-2-pyrrolidinyl]-3-pyridinyl]-

Base Information

Chemical Name:1H-Indole-4-carboxamide, N,N'-[1,2-ethanediylbis(oxy-3,1-propanediyl)]bis[1-[5-[(2S)-1-(N-methyl-L-alanyl-L-valyl)-2-pyrrolidinyl]-3-pyridinyl]-
CAS No.:1381992-68-2
Molecular Formula:C62H82N12O8
Molecular Weight:1123.41
Hs Code.:

1H-Indole-4-carboxamide, N,N'-[1,2-ethanediylbis(oxy-3,1-propanediyl)]bis[1-[5-[(2S)-1-(N-methyl-L-alanyl-L-valyl)-2-pyrrolidinyl]-3-pyridinyl]-

Synonyms:N,N'-[1,2-Ethanediylbis(oxy-3,1-propanediyl)]bis[1-[5-[(2S)-1-(N-methyl-L-alanyl-L-valyl)-2-pyrrolidinyl]-3-pyridinyl]-1H-indole-4-carboxamide

Suppliers and Price of 1H-Indole-4-carboxamide, N,N'-[1,2-ethanediylbis(oxy-3,1-propanediyl)]bis[1-[5-[(2S)-1-(N-methyl-L-alanyl-L-valyl)-2-pyrrolidinyl]-3-pyridinyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Indole-4-carboxamide, N,N'-[1,2-ethanediylbis(oxy-3,1-propanediyl)]bis[1-[5-[(2S)-1-(N-methyl-L-alanyl-L-valyl)-2-pyrrolidinyl]-3-pyridinyl]-

Chemical Property:

PSA：235.18000
LogP:8.38320

Purity/Quality:: 99% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of 1H-Indole-4-carboxamide, N,N'-[1,2-ethanediylbis(oxy-3,1-propanediyl)]bis[1-[5-[(2S)-1-(N-methyl-L-alanyl-L-valyl)-2-pyrrolidinyl]-3-pyridinyl]-

There total 7 articles about 1H-Indole-4-carboxamide, N,N'-[1,2-ethanediylbis(oxy-3,1-propanediyl)]bis[1-[5-[(2S)-1-(N-methyl-L-alanyl-L-valyl)-2-pyrrolidinyl]-3-pyridinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2997-01-5
1,2-bis(3-aminopropoxy)ethane

: 1381993-17-4
1-[5-((S)-1-{(S)-2-[(S)-2-(tert-butoxycarbonyl-methyl-amino)-propionylamino]-3-methyl-butyryl}-pyrrolidin-2-yl)-pyridin-3-yl]-1H-indole-4-carboxylic acid

: 1381992-68-2
(S,S,S)-N,N'-(3,3'-(ethane-1,2-diylbis(oxy))bis(propane-3,1-diyl))bis(1-(5-((S)-1-((S)-3-methyl-2-((S)-2-(methylamino)-propanamido)butanoyl)pyrrolidin-2-yl)pyridin-3-yl)-1H-indole-4-carboxamide)

Guidance literature:: 1-[5-((S)-1-{(S)-2-[(S)-2-(tert-butoxycarbonyl-methyl-amino)-propionylamino]-3-methyl-butyryl}-pyrrolidin-2-yl)-pyridin-3-yl]-1H-indole-4-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; at 0 ℃; for 0.25h;

1,2-bis(3-aminopropoxy)ethane; In tetrahydrofuran; at 0 - 20 ℃;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 50614-84-1
ethyl indole-4-carboxylate

: 1381992-68-2
(S,S,S)-N,N'-(3,3'-(ethane-1,2-diylbis(oxy))bis(propane-3,1-diyl))bis(1-(5-((S)-1-((S)-3-methyl-2-((S)-2-(methylamino)-propanamido)butanoyl)pyrrolidin-2-yl)pyridin-3-yl)-1H-indole-4-carboxamide)

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / copper(l) iodide / 1-methyl-pyrrolidin-2-one / 0.5 h / 190 °C / Microwave irradiation

2.1: 0.5 h / 100 °C / Microwave irradiation

3.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 21 h / 20 °C

4.2: 20 °C

4.3: 20 °C

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

5.2: pH 4

6.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0.25 h / 0 °C

6.2: 0 - 20 °C

6.3: 3 h / 20 °C

With water; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; copper(l) iodide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1005342-85-7
3-Bromo-5-{(S)-1-[(R)-1-(4-methoxy-phenyl)-ethyl]-pyrrolidin-2-yl}-pyridine

: 1381992-68-2
(S,S,S)-N,N'-(3,3'-(ethane-1,2-diylbis(oxy))bis(propane-3,1-diyl))bis(1-(5-((S)-1-((S)-3-methyl-2-((S)-2-(methylamino)-propanamido)butanoyl)pyrrolidin-2-yl)pyridin-3-yl)-1H-indole-4-carboxamide)

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / copper(l) iodide / 1-methyl-pyrrolidin-2-one / 0.5 h / 190 °C / Microwave irradiation

2.1: 0.5 h / 100 °C / Microwave irradiation

3.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 21 h / 20 °C

4.2: 20 °C

4.3: 20 °C

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

5.2: pH 4

6.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0.25 h / 0 °C

6.2: 0 - 20 °C

6.3: 3 h / 20 °C

With water; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; lithium hydroxide; copper(l) iodide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide;