Ethyl 1H-indole-4-carboxylate

Base Information

• Chemical Name: Ethyl 1H-indole-4-carboxylate
• CAS No.: 50614-84-1
• Molecular Formula: C11H11NO2
• Molecular Weight: 189.214
• Hs Code.: 2933990090
• Mol file: 50614-84-1.mol

Synonyms:Ethyl4-indolecarboxylate;Ethyl indole-4-carboxylate;

Chemical Property of Ethyl 1H-indole-4-carboxylate

Chemical Property:

• Vapor Pressure: 7.57E-05mmHg at 25°C
• Melting Point: 70-71 °C
• Refractive Index: 1.62
• Boiling Point: 342.4 °C at 760 mmHg
• PKA: 15.83±0.30(Predicted)
• Flash Point: 160.9 °C
• PSA: 42.09000
• Density: 1.21 g/cm³
• LogP: 2.34460
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethylindole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 1H-indole-4-carboxylate

There total 18 articles about Ethyl 1H-indole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-ethoxycarbonyl-1-tri-isopropylsilylindole (112447-71-9) → ethyl indole-4-carboxylate (50614-84-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/S0040-4020(01)86105-6

Reference yield: 98.0%

4-bromo-1H-indole (52488-36-5) + ethanol (64-17-5) + carbon monoxide (201230-82-2) → ethyl indole-4-carboxylate (50614-84-1)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; bis(benzonitrile)palladium(II) dichloride; triethylamine; at 130 ℃; for 20h; under 18751.5 Torr;

DOI:10.1021/ol035988r

Reference yield: 89.0%

1-(2,2-dimethyl-propionyl)-1H-indole-4-carboxylic acid ethyl ester → ethyl indole-4-carboxylate (50614-84-1)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; hexane; at 40 - 45 ℃; for 2h;

DOI:10.1055/s-2004-836060

upstream raw materials:

sodium ethanolate

5-amino-3-ethoxy-3,4-dihydroisocoumarin

4-ethoxycarbonyl-1-tri-isopropylsilylindole

1H-indole-4-carboxylic acid

Downstream raw materials:

(1H-indol-4-yl)methanol

ethyl 1-methyl-1H-indole-4-carboxylate

indole-4-isocyanate

1-methyl-1H-indole-4-carboxylic acid